TNFRSF10B 抗体 (Extracellular Domain)
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- 抗原 See all TNFRSF10B 抗体
- TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))
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抗原表位
- Extracellular Domain
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This TNFRSF10B antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS)
- 特异性
- The mouse monoclonal antibody DR5-01-1 recognizes an extracellular domain of TRAIL-R2 (DR5). TRAIL-R2 is one of two TNF superfamily members that contain death domain for TRAIL (APO2L).
- 交叉反应 （详细）
- Human
- 纯化方法
- Purified by protein-A affinity chromatography.
- 纯度
- > 95 % (by SDS-PAGE)
- 免疫原
- Recombinant fusion protein of human IgG heavy chain and extracellular domain of DR5.
- 克隆位点
- DR5-01-1
- 亚型
- IgG1
- Top Product
- Discover our top product TNFRSF10B Primary Antibody
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anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 234-435) antibody
TNFRSF10B 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 233-440) antibodyTNFRSF10B 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 1-440) antibodyTNFRSF10B 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 266-393) antibodyTNFRSF10B 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal DR5-3381 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 71-170) antibodyTNFRSF10B 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 2D6 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (N-Term) antibodyTNFRSF10B 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 56-210) antibodyTNFRSF10B 适用: 人 WB, FACS, ELISA, IHC, ICC, Neut 宿主: 小鼠 Monoclonal 2H5B8 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 301-381) antibodyTNFRSF10B 适用: 人 WB, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) antibodyTNFRSF10B 适用: 人, 小鼠 WB, ICC 宿主: 小鼠 Monoclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B) (AA 56-186) antibodyTNFRSF10B 适用: 人 FACS, ELISA 宿主: 兔 Monoclonal DM113 unconjugated
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- 应用备注
- Flow cytometry: Recommended dilution: 1-4 μg/mL, positive control: JURKAT human peripheral blood leukemia T cell line.
- 限制
- 仅限研究用
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- 浓度
- 1 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Do not freeze.
- 储存条件
- 4 °C
- 储存方法
- Store at 2-8°C. Do not freeze.
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- 抗原
- TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily, Member 10b (TNFRSF10B))
- 别名
- CD262 / TRAIL-R2 (TNFRSF10B 产品)
- 别名
- TNFRSF10B antibody, dr5 antibody, cd262 antibody, killer antibody, trick2 antibody, trickb antibody, xDR-M1 antibody, xDR-M2 antibody, ztnfr9 antibody, trailr2 antibody, trick2a antibody, trick2b antibody, CD262 antibody, DR5 antibody, KILLER antibody, KILLER/DR5 antibody, TRAIL-R2 antibody, TRAILR2 antibody, TRICK2 antibody, TRICK2A antibody, TRICK2B antibody, TRICKB antibody, ZTNFR9 antibody, Ly98 antibody, MK antibody, tumor necrosis factor receptor superfamily, member 10b antibody, tumor necrosis factor receptor superfamily member 10b S homeolog antibody, tumor necrosis factor receptor superfamily member 10b L homeolog antibody, tumor necrosis factor receptor superfamily member 10b antibody, TNF receptor superfamily member 10b antibody, Tnfrsf10b antibody, TNFRSF10B antibody, tnfrsf10b.S antibody, tnfrsf10b.L antibody, tnfrsf10b antibody
- 背景
- TNF receptor superfamily member 10b,TRAIL-R2 (CD262, DR5) is one of two TNF superfamily member intracellular death domain containing receptors for TRAIL (APO2L). Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including tumor necrosis factor (TNF) and Fas ligand in the TNF family through their death domain containing receptors, TNF receptor 1 (TNFR1) and Fas, respectively. Another member in the TNF family has been identified and designated TRAIL (for TNF related apoptosis inducing ligand) and Apo2L (for Apo2 ligand). Receptors for TRAIL include two death domain containing receptors, DR4 and DR5, as well as two decoy receptors, DcR1 and DcR2, lacking the intracellular signaling death domain. DcR1 (also called TRID), like the related death receptors DR4 and DR5, contains two extracellular cysteine rich domains. However, DcR1 contains no intracellular death domain and is thus incapable of signaling apoptosis. It has been suggested DcR1 is responsible for TRAIL resistance in normal human tissues including heart, placenta, lung, liver, kidney, spleen, and bone marrow. DR5 is a member of the TNF receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor related apoptosis inducing ligand (TNFSF10/TRAIL/APO2L), and transduces apoptosis signal. Studies with FADD deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein.,TNFRSF10B, KILLER, TRICK2, TRAIL-R2
- 基因ID
- 8795
- UniProt
- O14763
- 途径
- p53 Pathway, Apoptosis, Positive Regulation of Endopeptidase Activity
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