IL1RA is a naturally occurring inflammatory inhibitor protein. It inhibits the activity of IL1a and IL1beta by competitively blocking binding to their type I and type II receptors. IL1Ra is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts. Therapeutically, IL1Ra may help in the treatment of sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease. Synonyms: Monoclonal IL1RA antibody, Anti-IL1RA antibody, IL1 RA antibody, IL1-RA antibody, Interleukin 1 receptor antagonist antibody.