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JAK2 抗体 (AA 601-700) (Alexa Fluor 647)

Name: JAK2 抗体 (AA 601-700) (Alexa Fluor 647)
SKU: ABIN903218
Availability: OutOfStock

JAK2 适用: 人, 大鼠, 小鼠 WB, FACS, IF (cc), IF (p) 宿主: 兔 Polyclonal Alexa Fluor 647

产品编号 ABIN903218

发货至: 中国

Datasheet as PDF

抗原 See all JAK2 抗体

JAK2 (Janus Kinase 2 (JAK2))
抗原表位
37

34

16

15

12

10

8

7

6

6

6

6

6

5

3

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 601-700
适用
172

100

96

18

18

3

2

2

1
人, 大鼠, 小鼠
宿主
174

6

2
兔
Compatible Secondaries
克隆类型
158

24
多克隆
标记
93

15

9

6

6

6

6

6

6

5

5

3

3

3

3

3

3

1
This JAK2 antibody is conjugated to Alexa Fluor 647
应用范围
130

81

62

56

28

26

25

22

17

13

10

5

4

2

1

1

1
Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

交叉反应

人, 小鼠, 大鼠

预测反应

Dog,Cow,Pig,Chicken

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human JAK2

亚型

IgG

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anti-Janus Kinase 2 (JAK2) (AA 916-1103) antibody
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anti-Janus Kinase 2 (JAK2) (pTyr1007), (pTyr1008) antibody
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anti-Janus Kinase 2 (JAK2) antibody
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anti-Janus Kinase 2 (JAK2) (AA 745-955) antibody
JAK2 适用: 人 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 5C12C9 unconjugated

anti-Janus Kinase 2 (JAK2) (AA 508-800) antibody
JAK2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Janus Kinase 2 (JAK2) (pTyr931) antibody
JAK2 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Janus Kinase 2 (JAK2) (pTyr221) antibody
JAK2 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Janus Kinase 2 (JAK2) (pTyr1007), (pTyr1008) antibody
JAK2 适用: 人 WB, ELISA, IHC, IP 宿主: 兔 Monoclonal 1A4 unconjugated Recombinant Antibody

anti-Janus Kinase 2 (JAK2) (C-Term) antibody
JAK2 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

FCM 1:20-100
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

有效期

12 months
抗原

JAK2 (Janus Kinase 2 (JAK2))

别名

JAK2 (JAK2 产品)

别名

JAK2bCA antibody, jak2 antibody, JTK10 antibody, THCYT3 antibody, AI504024 antibody, C81284 antibody, Fd17 antibody, JAK-2 antibody, Janus kinase 2b antibody, Janus kinase 2 antibody, jak2b antibody, JAK2 antibody, Jak2 antibody

背景

Synonyms: JTK1, THCYT3, Tyrosine-protein kinase JAK2, Janus kinase 2, JAK-2, JAK2
Background: Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO), or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation. Plays a role in cell cycle by phosphorylating CDKN1B. Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin.

基因ID

3717

UniProt

O60674

途径

JAK/STAT Signaling, RTK signaling, Interferon-gamma Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Response to Growth Hormone Stimulus, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling, Unfolded Protein Response