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GABRB3 抗体 (pSer408, pSer409)

GABRB3 适用: 人, 大鼠, 小鼠, Cow, 犬, 小鸡, 斑马鱼, Non-Human Primate, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN784601
发货至: 中国
  • 抗原 See all GABRB3 抗体
    GABRB3 (gamma-aminobutyric Acid (GABA) A Receptor, beta 3 (GABRB3))
    抗原表位
    • 16
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer408, pSer409
    适用
    • 40
    • 38
    • 21
    • 9
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    人, 大鼠, 小鼠, Cow, 犬, 小鸡, 斑马鱼, Non-Human Primate, 非洲爪蟾
    宿主
    • 42
    • 6
    • 1
    • 1
    克隆类型
    • 44
    • 6
    多克隆
    标记
    • 26
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GABRB3 antibody is un-conjugated
    应用范围
    • 45
    • 18
    • 15
    • 13
    • 13
    • 12
    • 7
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    特异性
    The antibody has been directly tested for reactivity in Western blots with rat tissue. Specific for the ~53k GABAA receptor beta-3 subunit phosphorylated at Ser408/409. Immunolabeling of the GABAA band is completely blocked by the phospho-peptide used as antigen but not by the corresponding dephospho-peptide.
    交叉反应 (详细)
    Species reactivity (expected):Bovine, Canine, Chicken, Human, Mouse, non-Human primates, Xenopus and Zebrafish.
    Species reactivity (tested):Rat.
    纯化方法
    Affinity Chromatography.
    免疫原
    Phosphopeptide corresponding to amino acid residues surrounding the di-phospho- Ser408/409 of the Rat GABAA receptor, beta-3 subunit.
    亚型
    IgG
    Top Product
    Discover our top product GABRB3 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    -20 °C
    储存方法
    Store the antibody undiluted (in aliquots) at -20 °C.
  • 抗原
    GABRB3 (gamma-aminobutyric Acid (GABA) A Receptor, beta 3 (GABRB3))
    别名
    GABRB3 (GABRB3 产品)
    别名
    GABRB3 antibody, eca5 antibody, LOC100230475 antibody, ECA5 antibody, A230092K12Rik antibody, AW049585 antibody, Cp1 antibody, Gabrb-3 antibody, beta3 antibody, gamma-aminobutyric acid type A receptor beta3 subunit antibody, gamma-aminobutyric acid (GABA) A receptor, beta 3 antibody, gamma-aminobutyric acid type A receptor beta 3 subunit antibody, gamma-aminobutyric acid (GABA) A receptor, subunit beta 3 antibody, GABRB3 antibody, gabrb3 antibody, Gabrb3 antibody
    背景
    Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six Alpha's, four Beta's and four Gamma's, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990, Whiting et al., 1999, Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for Alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a Gamma-subunit is required for benzodiazepine modulation. Phosphorylation of Serine 408 and Serine 409 within the Beta-3 subunit have been shown to be critical for the functional modulation of Beta-3 containing recombinant receptors (Brandon et al., 2000).Synonyms: GABA A receptor subunit beta-3, GABRB-3, Gamma-aminobutyric acid receptor subunit beta-3
    基因ID
    24922
    NCBI登录号
    NP_058761
    途径
    Sensory Perception of Sound
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