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CD163 抗体 (AA 1001-1121)

Name: CD163 抗体 (AA 1001-1121)
SKU: ABIN741570
Availability: OutOfStock

CD163 适用: 人, 小鼠, 大鼠, Pig, 犬 WB, FACS, ELISA, IHC (p), IHC (fro), ICC, IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated

Formalin-fixed and paraffin embedded mouse intestine labeled with Rabbit Anti CD163 Polyclonal Antibody, Unconjugated (ABIN741570) at 1:200 followed by conjugation to the secondary antibody and DAB staining

IHC

Chronic phase glibenclamide reduces inflammation and improves the macrophage phenotype in EAE.

IHC (p)

Formalin-fixed and paraffin embedded Human testis tissue labeled with unconjugated Anti-CD163/M130 Polyclonal Antibody, unconjugated at 1:100 for 40 minutes at 37°C followed by labeling Donkey Anti-Rabbit, Cy3 conjugated 1:300, 60 minutes at 37°C.

IF (p)

Mouse splenocytes probed with Rabbit Anti-CD163/M130 Polyclonal Antibody, PE-Cy5.

7 images

(27 references)

产品编号 ABIN741570

发货至: 中国

Datasheet as PDF

抗原 See all CD163 抗体

CD163
抗原表位
16

15

15

11

8

6

6

4

4

3

3

2

2

2

2

2

2

2

1

1

1

1

1
AA 1001-1121
适用
128

49

29

28

19

5

4

1
人, 小鼠, 大鼠, Pig, 犬
宿主
108

44

1
兔
Compatible Secondaries
克隆类型
92

60

1
多克隆
标记
55

18

12

8

6

6

4

4

4

4

4

4

3

3

3

3

3

2

1

1

1

1

1

1

1
This CD163 antibody is un-conjugated
应用范围
110

70

50

38

26

25

25

23

21

20

14

5

4

3

3

2

2

2

1

1

1
Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

交叉反应

犬, 人, 小鼠, Pig, 大鼠

预测反应

Horse

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human CD163/M130

亚型

IgG
anti-CD163 (CD163) (AA 1001-1121) antibody (FITC)
CD163 适用: 人, 小鼠, 大鼠, Pig, 犬 WB, FACS, IF (cc), IF (p) 宿主: 兔 Polyclonal FITC

anti-CD163 (CD163) (AA 43-196) antibody
CD163 适用: 人 IHC, ELISA, ISt, Coat, StM 宿主: 小鼠 Monoclonal M130-2162 unconjugated

anti-CD163 (CD163) (AA 43-196) antibody
CD163 适用: 人 WB, IHC, ISt, StM 宿主: 小鼠 Monoclonal M130-1210 unconjugated

anti-CD163 (CD163) (AA 42-259) antibody
CD163 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 小鼠 Monoclonal 7G5E2 unconjugated

anti-CD163 (CD163) (AA 697-972) antibody
CD163 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-CD163 (CD163) antibody
CD163 适用: 人 WB, FACS, IP, IHC (fro) 宿主: 小鼠 Monoclonal GHI-61 unconjugated

anti-CD163 (CD163) (AA 42-259) antibody
CD163 适用: 人 WB, FACS, ELISA 宿主: 小鼠 Monoclonal 8B7D11 unconjugated

anti-CD163 (CD163) (AA 47-201) antibody
CD163 适用: 人, 小鼠, 大鼠 WB, FACS, IHC, ELISA, ICC 宿主: 兔 Polyclonal unconjugated

anti-CD163 (CD163) (AA 1092-1109), (C-Term) antibody
CD163 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-CD163 (CD163) (AA 693-939) antibody
CD163 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
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Gerzanich, Makar, Guda, Kwon, Stokum, Woo, Ivanova, Ivanov, Mehta, Morris, Bryan, Bever, Simard: "Salutary effects of glibenclamide during the chronic phase of murine experimental autoimmune encephalomyelitis." in: Journal of neuroinflammation, Vol. 14, Issue 1, pp. 177, (2017) (PubMed).

Lee, Liao, Wang, Yang, Luo, Varki, Qiu, Ren, Fu, Feng: "Preventive Inhibition of Liver Tumorigenesis by Systemic Activation of Innate Immune Functions." in: Cell reports, Vol. 21, Issue 7, pp. 1870-1882, (2017) (PubMed).

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Tauchi, Tanaka, Kumamoto, Tokumoto, Sakimura, Sakurai, Kimura, Toyokawa, Amano, Kubo, Muguruma, Yashiro, Maeda, Ohira, Hirakawa: "Tumor-associated macrophages induce capillary morphogenesis of lymphatic endothelial cells derived from human gastric cancer." in: Cancer science, Vol. 107, Issue 8, pp. 1101-9, (2017) (PubMed).

Jacobsen, Mentzel, Olesen, Huby, Jørgensen, Barrès, Fredholm, Simar: "Altered Methylation Profile of Lymphocytes Is Concordant with Perturbation of Lipids Metabolism and Inflammatory Response in Obesity." in: Journal of diabetes research, Vol. 2016, pp. 8539057, (2016) (PubMed).

Kugo, Zaima, Tanaka, Mouri, Yanagimoto, Hayamizu, Hashimoto, Sasaki, Sano, Yata, Urano, Setou, Unno, Moriyama: "Adipocyte in vascular wall can induce the rupture of abdominal aortic aneurysm." in: Scientific reports, Vol. 6, pp. 31268, (2016) (PubMed).

Drel, Tan, Barnes, Gorin, Lee, Wagner: "Centrality of bone marrow in the severity of gadolinium-based contrast-induced systemic fibrosis." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 30, Issue 9, pp. 3026-38, (2016) (PubMed).

Das, Singh, Majid, Sherman, Mukhopadhyay, Wright, Martin, Dunn, Baker: "Syndesome Therapeutics for Enhancing Diabetic Wound Healing." in: Advanced healthcare materials, Vol. 5, Issue 17, pp. 2248-60, (2016) (PubMed).

Chen, Shi, Zhang, Chen, Wang, Zhang, Tian, Yan, Li, Zhong, Xing, Zhang, Zhang: "Mesenchymal stem cell-laden anti-inflammatory hydrogel enhances diabetic wound healing." in: Scientific reports, Vol. 5, pp. 18104, (2016) (PubMed).

Fernandez-Bustamante, Agazio, Wilson, Elkins, Domaleski, He, Baer, Moss, Wischmeyer, Repine et al.: "Brief Glutamine Pretreatment Increases Alveolar Macrophage CD163/Heme Oxygenase-1/p38-MAPK Dephosphorylation Pathway and Decreases Capillary Damage but Not Neutrophil Recruitment in ..." in: PLoS ONE, Vol. 10, Issue 7, pp. e0130764, (2016) (PubMed).

Tepeköylü, Lobenwein, Blunder, Kozaryn, Dietl, Ritschl, Pechriggl, Blumer, Bitsche, Schistek, Kotsch, Fritsch, Grimm, Holfeld: "Alteration of inflammatory response by shock wave therapy leads to reduced calcification of decellularized aortic xenografts in mice†." in: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, Vol. 47, Issue 3, pp. e80-90, (2015) (PubMed).

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Franken, Klein, Spasova, Elsukova, Wiedwald, Welz, Knolle, Farle, Limmer, Kurts: "Splenic red pulp macrophages are intrinsically superparamagnetic and contaminate magnetic cell isolates." in: Scientific reports, Vol. 5, pp. 12940, (2015) (PubMed).
抗原

CD163

别名

Cd163/M130 (CD163 产品)

别名

DMBT1 antibody, CD163 antibody, CD163v2 antibody, CD163v3 antibody, M130 antibody, MM130 antibody, deleted in malignant brain tumors 1 protein-like antibody, CD163 molecule antibody, CD163 antigen antibody, LOC426820 antibody, CD163 antibody, Cd163 antibody

背景

Synonyms: M13, MM13, Scavenger receptor cysteine-rich type 1 protein M13, Hemoglobin scavenger receptor, CD163, M130
Background: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH -dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.

基因ID

9332

UniProt

Q86VB7