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FLT1 抗体 (AA 1162-1260)

Name: FLT1 抗体 (AA 1162-1260)
SKU: ABIN725795
Availability: OutOfStock

FLT1 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IHC (p), ICC, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

Rat lung lysates 30ug, probed at 1:200 overnight in 4˚C.

Formalin-fixed and paraffin embedded rat brain tissue labeled with Anti-VEGFR1/FLT1 Polyclonal Antibody, Unconjugated (ABIN725795) at 1:400 followed by conjugation to the secondary antibody and DAB staining

IHC

Mouse spleen cells probed with VEGFR1 Polyclonal Antibody, unconjugated at 1:100 dilution for 30 minutes compared to control cells (blue) and isotype control (orange)

Image kindly submitted by Victor Blanco as part of the Free Sample Program.

Rat lung lysates 30ug, probed (ABIN725795) at 1:200 overnight in 4 °C.

SDS

Formalin-fixed and paraffin embedded rat brain tissue labeled with Anti-VEGFR1/FLT1 Polyclonal Antibody, Unconjugated at 1:400 followed by conjugation to the secondary antibody and DAB staining

IHC (p)

6 images

(4 references)

产品编号 ABIN725795

发货至: 中国

Datasheet as PDF

抗原 See all FLT1 抗体

FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))
抗原表位
15

12

11

11

7

7

7

5

4

4

4

4

4

4

3

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 1162-1260
适用
143

65

64

12

3

2

2

2

2

1

1

1

1

1

1

1
人, 大鼠, 小鼠
宿主
140

32

3

1
兔
Compatible Secondaries
克隆类型
141

35
多克隆
标记
92

22

11

5

5

5

5

5

5

3

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This FLT1 antibody is un-conjugated
应用范围
110

49

43

35

23

23

20

14

13

12

8

5

3

2

1

1

1
Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

交叉反应

人, 小鼠, 大鼠

预测反应

Pig,Horse

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from rat VEGFR1

亚型

IgG
anti-Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) (AA 20-300) antibody
FLT1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) (pTyr1213) antibody
FLT1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) (AA 1100-1200) antibody
FLT1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) antibody
FLT1 适用: 人, 大鼠, 小鼠 IHC 宿主: 兔 Polyclonal unconjugated

anti-Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) (AA 1-687) antibody
FLT1 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated

anti-Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) (AA 1251-1338) antibody
FLT1 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal unconjugated

anti-Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) antibody
FLT1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB16736 unconjugated

anti-Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) (pTyr1048) antibody
FLT1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) (AA 18-308) antibody
FLT1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1) (AA 1048-1328) antibody
FLT1 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Liu, Zou, Li, Wang, Wang, Hao, Ke, Li: "RUNX3 modulates hypoxia-induced endothelial-to-mesenchymal transition of human cardiac microvascular endothelial cells." in: International journal of molecular medicine, Vol. 40, Issue 1, pp. 65-74, (2017) (PubMed).

Cheng, Xiang, Yang, Ma, Zhao: "Direct Effects of Bevacizumab on Rat Conjunctival Fibroblast." in: Cell biochemistry and biophysics, (2015) (PubMed).

Liu, Wang, Wang, Wang, Xue: "Paeoniflorin attenuates A?1-42-induced inflammation and chemotaxis of microglia in vitro and inhibits NF-?B- and VEGF/Flt-1 signaling pathways." in: Brain research, Vol. 1618, pp. 149-58, (2015) (PubMed).

Wang, Hao, Shi, Pu, Wang: "Effects of minocycline on apoptosis and angiogenesis-related protein expression in a rat model of intracerebral hemorrhage." in: Neural regeneration research, Vol. 7, Issue 8, pp. 595-600, (2015) (PubMed).
抗原

FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))

别名

VEGFR1 (FLT1 产品)

别名

FLT antibody, FLT-1 antibody, VEGFR-1 antibody, VEGFR1 antibody, FLT1 antibody, flt1b antibody, sFlt1 antibody, AI323757 antibody, Flt-1 antibody, fms related tyrosine kinase 1 antibody, FMS-related tyrosine kinase 1 antibody, vascular endothelial growth factor receptor 1 antibody, fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) antibody, FMS-like tyrosine kinase 1 antibody, vascular endothelial growth factor receptor-1 antibody, FLT1 antibody, Flt1 antibody, CpipJ_CPIJ012087 antibody, flt1 antibody, FLT-1 antibody

背景

Synonyms: VEGFR-1, Vascular endothelial growth factor receptor 1, Fms-like tyrosine kinase 1, FLT-1, Tyrosine-protein kinase receptor FLT, Flt1, Vegfr1
Background: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. Can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific. Promotes PGF-mediated proliferation of endothelial cells, and proliferation of some types of cancer cells, but does not promote proliferation of normal fibroblasts. Has very high affinity for VEGFA and relatively low protein kinase activity, may function as a negative regulator of VEGFA signaling by limiting the amount of free VEGFA and preventing its binding to KDR. Modulates KDR signaling by forming heterodimers with KDR. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate and the activation of protein kinase C. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leading to the activation of phosphatidylinositol kinase and the downstream signaling pathway. Mediates activation of MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Phosphorylates SRC, YES1 and PLCG, and may also phosphorylate CBL. Promotes phosphorylation of AKT1 and PTK2/FAK1 (By similarity).

基因ID

54251

UniProt

P53767

途径

RTK signaling, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals