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BACE1 抗体 (AA 401-501)

Name: BACE1 抗体 (AA 401-501)
SKU: ABIN725705
Availability: OutOfStock

BACE1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), ICC, FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

Mouse muscle lysates probed with Rabbit Anti-BACE1 Polyclonal Antibody, Unconjugated at 1:5000 for 90 min at 37˚C.

Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti BACE1/ASP2 Polyclonal Antibody, Unconjugated (ABIN725705) at 1:200 followed by conjugation to the secondary antibody and DAB staining

IHC

L1 rat brain lysates probed with Anti BACE1/ASP2 Polyclonal Antibody, Unconjugated (ABIN725705) at 1:200 overnight at 4 °C.

SDS

3 images

(5 references)

产品编号 ABIN725705

发货至: 中国

Datasheet as PDF

抗原 See all BACE1 抗体

BACE1 (Beta-secretase 1 (BACE1))
抗原表位
15

13

6

5

5

4

3

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 401-501
适用
81

51

40

7

6

5

5

5

5

5

4

3

3

1

1

1

1
人, 小鼠, 大鼠
宿主
75

11
兔
Compatible Secondaries
克隆类型
71

15
多克隆
标记
55

4

4

3

2

2

2

2

2

2

2

1

1

1

1

1

1
This BACE1 antibody is un-conjugated
应用范围
63

36

29

17

13

12

12

11

11

6

3

3

2

2

2
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

交叉反应

人, 小鼠, 大鼠

预测反应

Dog,Pig,Chicken,Rabbit,Guinea Pig

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human BACE1

亚型

IgG

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anti-Beta-secretase 1 (BACE1) (N-Term) antibody
BACE1 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 马, 兔, 斑马鱼 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

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BACE1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Beta-secretase 1 (BACE1) (AA 46-155) antibody
BACE1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Beta-secretase 1 (BACE1) (C-Term) antibody
BACE1 适用: 人, 猴 IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Beta-secretase 1 (BACE1) (AA 72-121) antibody
BACE1 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 马, 兔, 猴, Pig, Hamster, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Beta-secretase 1 (BACE1) (AA 38-70), (N-Term) antibody
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anti-Beta-secretase 1 (BACE1) (AA 170-428) antibody
BACE1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
Ku, Li, Gao, Zhang, Yan, Ji, Li, Sang: "NF-κB-regulated microRNA-574-5p underlies synaptic and cognitive impairment in response to atmospheric PM2.5 aspiration." in: Particle and fibre toxicology, Vol. 14, Issue 1, pp. 34, (2018) (PubMed).

Hong, Shen, Yin, Sun, Ma, Liu: "Effects of RAGE-Specific Inhibitor FPS-ZM1 on Amyloid-β Metabolism and AGEs-Induced Inflammation and Oxidative Stress in Rat Hippocampus." in: Neurochemical research, Vol. 41, Issue 5, pp. 1192-9, (2016) (PubMed).

Yan, Yun, Ku, Li, Sang: "NO2 inhalation promotes Alzheimer's disease-like progression: cyclooxygenase-2-derived prostaglandin E2 modulation and monoacylglycerol lipase inhibition-targeted medication." in: Scientific reports, Vol. 6, pp. 22429, (2016) (PubMed).

Jiao, Kong, Yao, Li, Tao, Yan, Yang: "Osthole decreases beta amyloid levels through up-regulation of miR-107 in Alzheimer's disease." in: Neuropharmacology, Vol. 108, pp. 332-44, (2016) (PubMed).

Tian, Guo, Wu, Ma, Zhao: "Minocycline Alleviates Sevoflurane-Induced Cognitive Impairment in Aged Rats." in: Cellular and molecular neurobiology, (2015) (PubMed).
抗原

BACE1 (Beta-secretase 1 (BACE1))

别名

BACE1 (BACE1 产品)

别名

ASP2 antibody, BACE antibody, HSPC104 antibody, C76936 antibody, Bace antibody, MGC145931 antibody, BACE1 antibody, zgc:77409 antibody, beta-secretase 1 antibody, beta-site APP cleaving enzyme 1 antibody, beta-site APP-cleaving enzyme 1 antibody, BACE1 antibody, Bace1 antibody, bace1 antibody

背景

Synonyms: ASP2, BACE, HSPC104, Beta-secretase 1, Aspartyl protease 2, Asp 2, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, Memapsin-2, Membrane-associated aspartic protease 2, BACE1, KIAA1149
Background: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.

基因ID

23621

UniProt

P56817