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APEX2 抗体 (AA 301-400) (FITC)

APEX2 适用: 大鼠, 小鼠 WB 宿主: 兔 Polyclonal FITC
产品编号 ABIN718488
发货至: 中国
  • 抗原 See all APEX2 抗体
    APEX2 (APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2))
    抗原表位
    • 14
    • 7
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 301-400
    适用
    • 21
    • 15
    • 14
    大鼠, 小鼠
    宿主
    • 34
    • 2
    克隆类型
    • 36
    多克隆
    标记
    • 13
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This APEX2 antibody is conjugated to FITC
    应用范围
    • 34
    • 17
    • 15
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB)
    交叉反应
    小鼠, 大鼠
    预测反应
    Human
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human APEX2
    亚型
    IgG
    Top Product
    Discover our top product APEX2 Primary Antibody
  • 应用备注
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    有效期
    12 months
  • 抗原
    APEX2 (APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2))
    别名
    APEX2 (APEX2 产品)
    别名
    APE2 antibody, APEXL2 antibody, XTH2 antibody, ape2 antibody, apexl2 antibody, xth2 antibody, zgc:55889 antibody, C430040P13Rik antibody, apurinic/apyrimidinic endodeoxyribonuclease 2 antibody, APEX nuclease (apurinic/apyrimidinic endonuclease) 2 antibody, apurinic/apyrimidinic endodeoxyribonuclease 2 L homeolog antibody, apurinic/apyrimidinic endonuclease 2 antibody, APEX2 antibody, apex2 antibody, apex2.L antibody, Apex2 antibody
    背景

    Synonyms: APE2, XTH2, ZGRF2, APEXL2, DNA-(apurinic or apyrimidinic site) lyase 2, AP endonuclease XTH2, APEX nuclease 2, APEX nuclease-like 2, Apurinic-apyrimidinic endonuclease 2, AP endonuclease 2, APEX2

    Background: Function as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes.

    基因ID
    27301
    UniProt
    Q9UBZ4
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