The protein encoded by this gene mediates transcriptional control by interaction with the Kruppel-associated box repression domain found in many transcription factors. The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of the tripartite motif family. This tripartite motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. [provided by RefSeq, Jul 2008],KAP1,PPP1R157,RNF96,TF1B,TIF1B,TRIM28,Apoptosis,Cancer,Cell Biology & Developmental Biology,Epigenetics & Nuclear Signaling,Invasion and Metastasis,Protein phosphorylation,Transcription Factors,Ubiquitin,TRIM28