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METTL16 抗体 (AA 263-562)

METTL16 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN7268501
发货至: 中国
  • 抗原 See all METTL16 抗体
    METTL16 (Methyltransferase Like 16 (METTL16))
    抗原表位
    • 7
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 263-562
    适用
    • 22
    • 16
    • 7
    • 6
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    宿主
    • 18
    • 4
    克隆类型
    • 18
    • 4
    多克隆
    标记
    • 17
    • 1
    • 1
    • 1
    • 1
    • 1
    This METTL16 antibody is un-conjugated
    应用范围
    • 20
    • 8
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
    原理
    METTL16 Rabbit pAb
    序列
    RIQGVPKVTY TEFCQGRTMR WALAWSFYDD VTVPSPPSKR RKLEKPRKPI TFVVLASVMK ELSLKASPLR SETAEGIVVV TTWIEKILTD LKVQHKRVPC GKEEVSLFLT AIENSWIHLR RKKRERVRQL REVPRAPEDV IQALEEKKPT PKESGNSQEL ARGPQERTPC GPALREGEAA AVEGPCPSQE SLSQEENPEP TEDERSEEKG GVEVLESCQG SSNGAQDQEA SEQFGSPVAE RGKRLPGVAG QYLFKCLINV KKEVDDALVE MHWVEGQNRD LMNQLCTYIR NQIFRLVAVN
    交叉反应
    人, 小鼠, 大鼠
    产品特性
    Polyclonal Antibodies
    纯化方法
    Affinity purification
    免疫原
    Recombinant fusion protein containing a sequence corresponding to amino acids 263-562 of human METTL16 (NP_076991.3).
    亚型
    IgG
  • 应用备注
    WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200,IP,1:50 - 1:200
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    METTL16 (Methyltransferase Like 16 (METTL16))
    别名
    METTL16 (METTL16 产品)
    别名
    fi09d09 antibody, im:7148386 antibody, mett10d antibody, wu:fi09d09 antibody, zgc:100981 antibody, zgc:158576 antibody, METT10D antibody, 2610100D03Rik antibody, 2810013M15Rik antibody, A830095F14Rik antibody, AI846133 antibody, Mett10d antibody, methyltransferase like 16 antibody, methyltransferase like 16 L homeolog antibody, mettl16 antibody, mettl16.L antibody, METTL16 antibody, Mettl16 antibody
    背景
    RNA N6-methyltransferase that methylates adenosine residues at the N(6 position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs. In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, preventing recognition of their 3'-splice site by U2AF1/U2AF35, thereby inhibiting splicing and protein production of S-adenosylmethionine synthase. In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A. In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA: specifically N6-methylates adenine in position 43 of U6 snRNAs. Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA or 7SL RNA. Specifically binds the 3'-end of the MALAT1 long non-coding RNA.,METTL16,METT10D,Epigenetics & Nuclear Signaling,RNA Binding,Cell Biology & Developmental Biology,METTL16
    分子量
    25kDa/63kDa
    基因ID
    79066
    UniProt
    Q86W50
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