GSK3 alpha 抗体 (pSer21)
(1 reference)-
- 抗原 See all GSK3 alpha (GSK3a) 抗体
- GSK3 alpha (GSK3a) (Glycogen Synthase Kinase 3 alpha (GSK3a))
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抗原表位
- pSer21
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适用
- 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This GSK3 alpha antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 特异性
- This phosphorylation site is homologous to that of Ser21 in Mouse and Rat.
- 交叉反应
- 小鼠, 大鼠
- 预测反应
- Human,Dog,Pig,Horse,Chicken
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic phosphopeptide derived from human GSK3 Alpha around the phosphorylation site of Ser21
- 亚型
- IgG
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anti-Glycogen Synthase Kinase 3 alpha (GSK3a) (pSer21) antibody
GSK3a 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Glycogen Synthase Kinase 3 alpha (GSK3a) (AA 122-406) antibodyGSK3a 适用: 小鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Glycogen Synthase Kinase 3 alpha (GSK3a) (AA 76-105), (N-Term) antibodyGSK3a 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB3817-3818 unconjugated
anti-Glycogen Synthase Kinase 3 alpha (GSK3a) (pSer21) antibodyGSK3a 适用: 人, 小鼠, 兔 WB, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Glycogen Synthase Kinase 3 alpha (GSK3a) (AA 409-483) antibodyGSK3a 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Glycogen Synthase Kinase 3 alpha (GSK3a) antibodyGSK3a 适用: 人 WB, ELISA, ICC 宿主: 小鼠 Monoclonal 9D5G1 unconjugated
anti-Glycogen Synthase Kinase 3 alpha (GSK3a) antibodyGSK3a 适用: 人 WB, IHC, ELISA 宿主: 小鼠 Monoclonal 6G2F1 unconjugated
anti-Glycogen Synthase Kinase 3 alpha (GSK3a) (Ser21) antibodyGSK3a 适用: 人, 小鼠, 大鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Glycogen Synthase Kinase 3 alpha (GSK3a) (AA 36-118) antibodyGSK3a 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Glycogen Synthase Kinase 3 alpha (GSK3a) (AA 348-382) antibodyGSK3a 适用: 小鼠, 大鼠 WB 宿主: 兔 Polyclonal RB30809 unconjugated
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- 应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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: "Decrease in male mouse fertility by hydrogen sulfide and/or ammonia can Be inheritable." in: Chemosphere, Vol. 194, pp. 147-157, (2018) (PubMed).
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: "Decrease in male mouse fertility by hydrogen sulfide and/or ammonia can Be inheritable." in: Chemosphere, Vol. 194, pp. 147-157, (2018) (PubMed).
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- 抗原
- GSK3 alpha (GSK3a) (Glycogen Synthase Kinase 3 alpha (GSK3a))
- 别名
- GSK3 Alpha (GSK3a 产品)
- 别名
- 2700086H06Rik antibody, GSK3A antibody, GSK-3[a] antibody, GSK-3[b] antibody, GSK3 antibody, gsk3a antibody, xgsk3 antibody, glycogen synthase kinase 3 alpha antibody, glycogen synthase kinase 3 alpha b antibody, glycogen synthase kinase 3 alpha S homeolog antibody, GSK3A antibody, Gsk3a antibody, gsk3a antibody, gsk3ab antibody, gsk3a.S antibody, Bm1_31380 antibody
- 背景
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Synonyms: Glycogen synthase kinase-3 alpha, GSK-3 alpha, Serine/threonine-protein kinase GSK3A, GSK3A
Background: Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.
- 基因ID
- 2931
- UniProt
- P49840
- 途径
- PI3K-Akt Signaling, WNT signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, cAMP Metabolic Process, Cellular Glucan Metabolic Process, Regulation of Muscle Cell Differentiation, Regulation of G-Protein Coupled Receptor Protein Signaling, ER-Nucleus Signaling, Regulation of Carbohydrate Metabolic Process, BCR Signaling, Warburg Effect
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