NUDT16 抗体
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- 抗原 See all NUDT16 抗体
- NUDT16 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 16 (NUDT16))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This NUDT16 antibody is un-conjugated
- 应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
- 纯化方法
- Immunogen affinity purified
- 纯度
- ≥95 % as determined by SDS-PAGE
- 免疫原
- nudix(nucleoside diphosphate linked moiety X)-type motif 16
- 亚型
- IgG
- Top Product
- Discover our top product NUDT16 Primary Antibody
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anti-Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 16 (NUDT16) (AA 45-94) antibody
NUDT16 适用: 人, 小鼠, 犬, 豚鼠, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 16 (NUDT16) (AA 60-130) antibodyNUDT16 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 16 (NUDT16) (N-Term) antibodyNUDT16 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 兔, Cow, 马, 绵羊 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:1000-1:4000, IP: 1:500-1:2000, IHC: 1:20-1:200, IF: 1:20-1:200
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
- 有效期
- 12 months
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- 抗原
- NUDT16 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 16 (NUDT16))
- 别名
- NUDT16 (NUDT16 产品)
- 别名
- RGD1311387 antibody, 2310041H06Rik antibody, 2810047L04Rik antibody, 2900006H04Rik antibody, AI851783 antibody, x29 antibody, nudix hydrolase 16 antibody, nudix (nucleoside diphosphate linked moiety X)-type motif 16 antibody, nudix hydrolase 16 L homeolog antibody, Nudt16 antibody, NUDT16 antibody, nudt16.L antibody
- 背景
- Synonyms:Nudix motif 16, NUDT16, U8 snoRNA binding protein H29K, U8 snoRNA decapping enzyme Background:RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal-dependent manner. Part of the U8 snoRNP complex that is required for the accumulation of mature 5.8S and 28S rRNA. Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5'monophosphate on the RNA. Catalyzes also the cleavage of the cap structure on mRNAs. Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate(m7GpppG). Also hydrolysis m7G-and m227G U3-capped RNAs but with less efficiencies. Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species. Binds to the U8 snoRNA, metal is not required for RNA-binding. May play a role in the regulation of snoRNAs and mRNAs degradation. Acts also as a phosphatase, hydrolyzes the non-canonical purine nucleotides inosine diphosphate(IDP) and deoxyinosine diphosphate(dITP) as well as guanosine diphosphate(GDP), deoxyguanosine diphosphate(dGDP), xanthine diphosphate(XDP), inosine triphosphate(ITP) and deoxyinosine triphosphate(ITP) to their respective monophosphate derivatives and does not distinguish between the deoxy-and ribose forms(PubMed:20385596, PubMed:26121039). The order of activity with different substrates is IDP > dIDP >> GDP = dGDP > XDP = ITP = dITP(PubMed:20385596). Binds strongly to GTP, ITP and XTP. Participates in the hydrolysis of dIDP/IDP and probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions(PubMed:20385596).
- 分子量
- 21 kDa
- 基因ID
- 131870
- UniProt
- Q96DE0
- 途径
- Positive Regulation of Response to DNA Damage Stimulus
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