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BRCA2 抗体
BRCA2
适用: 人, 大鼠
IF
宿主: 兔
Polyclonal
unconjugated
BRCA2抗体详情
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抗原
See all BRCA2 抗体
BRCA2
(Breast Cancer 2, Early Onset (BRCA2))
适用
All reactivities for BRCA2 抗体
人, 大鼠
宿主
All hosts for BRCA2 抗体
兔
克隆类型
All clonalities for BRCA2 抗体
多克隆
标记
All conjugates for BRCA2 抗体
This BRCA2 antibody is un-conjugated
应用范围
All applications for BRCA2 抗体
Immunofluorescence (IF)
产品特性
Polyclonal Antibody
纯化方法
Affinity purification
免疫原
Recombinant fusion protein of human BRCA2 (NP_000050.2).
亚型
IgG
Top Product
Discover our top product BRCA2 Primary Antibody
Alternatives
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使用细节
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应用备注
IF 1:50-1:200
限制
仅限研究用
贮存及处理
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状态
Liquid
浓度
1 mg/mL
缓冲液
PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
-20 °C
储存方法
Store at -20°C. Avoid freeze / thaw cycles.
BRCA2目标详情
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抗原
BRCA2
(Breast Cancer 2, Early Onset (BRCA2))
别名
BRCA2 (BRCA2 产品 )
别名
BRCC2 antibody, BROVCA2 antibody, FACD antibody, FAD antibody, FAD1 antibody, FANCB antibody, FANCD antibody, FANCD1 antibody, GLM3 antibody, PNCA2 antibody, 30169 antibody, BcDNA:SD25109 antibody, CG13583 antibody, CG13584 antibody, CG30169 antibody, Dmel\\CG30169 antibody, brca2 antibody, dmbrca2 antibody, fancd1 antibody, BRCA2 antibody, brcc2 antibody, brovca2 antibody, facd antibody, fad antibody, fad1 antibody, fancb antibody, AI256696 antibody, AW045498 antibody, Fancd1 antibody, RAB163 antibody, BRCA2, DNA repair associated antibody, Breast cancer 2, early onset homolog antibody, breast cancer 2, early onset antibody, BRCA2 antibody, Brca2 antibody, brca2 antibody, LOC584780 antibody
背景
Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele.
基因ID
675
UniProt
P51587
途径
DNA Damage Repair , M Phase , Maintenance of Protein Location
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