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PAK1/2/3 抗体 (pSer139, pSer141, pSer144)

PAK1/2/3 适用: 人, 大鼠, 小鼠 IHC, WB, IHC (p), IF (cc), FACS 宿主: 兔 Monoclonal 9A3 unconjugated
产品编号 ABIN6944410
发货至: 中国
  • 抗原 See all PAK1/2/3 抗体
    PAK1/2/3 (P21-Activated Kinases 1/2/3 (PAK1/2/3))
    抗原表位
    • 13
    • 12
    • 11
    • 11
    • 7
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer139, pSer141, pSer144
    适用
    • 35
    • 27
    • 26
    • 1
    • 1
    • 1
    人, 大鼠, 小鼠
    宿主
    • 36
    克隆类型
    • 34
    • 2
    单克隆
    标记
    • 29
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PAK1/2/3 antibody is un-conjugated
    应用范围
    • 21
    • 20
    • 19
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Flow Cytometry (FACS)
    交叉反应
    人, 小鼠, 大鼠
    纯化方法
    Purified by Protein A.
    免疫原
    Synthetic phospho-peptide surrounding S139+S141+S144 of PAK
    克隆位点
    9A3
    亚型
    IgG
    Top Product
    Discover our top product PAK1/2/3 Primary Antibody
  • 应用备注
    WB(1:300-1000), FCM(1:20-100), IF(ICC)(1:50-200), IHC()
    限制
    仅限研究用
  • 浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C for 12 months.
    有效期
    12 months
  • 抗原
    PAK1/2/3 (P21-Activated Kinases 1/2/3 (PAK1/2/3))
    别名
    PAK1, PAK2, PAK3 (PAK1/2/3 产品)
    别名
    X-PAK1 antibody, XPak1 antibody, pak antibody, pak-1 antibody, pakalpha antibody, p21 protein (Cdc42/Rac)-activated kinase 1 S homeolog antibody, p21 (RAC1) activated kinase 1 antibody, pak1.S antibody, PAK1 antibody
    背景

    Synonyms: Serine/threonine-protein kinase PAK 1, Alpha-PAK, p21-activated kinase 1, p65-PAK, Serine/threonine-protein kinase PAK 2, Gamma-PAK, PAK65, S6/H4 kinase, p21-activated kinase 2, p58, Serine/threonine-protein kinase PAK 3, Beta-PAK, Oligophrenin-3, p21-activated kinase 3, PAK-1, PAK1, PAK-2, PAK2, PAK-3, PAK3

    Background: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development.

    基因ID
    5063
    UniProt
    O75914
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