PAK1/2/3 抗体 (pSer139, pSer141, pSer144)
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- 抗原 See all PAK1/2/3 抗体
- PAK1/2/3 (P21-Activated Kinases 1/2/3 (PAK1/2/3))
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抗原表位
- pSer139, pSer141, pSer144
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适用
- 人, 大鼠, 小鼠
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宿主
- 兔
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克隆类型
- 单克隆
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标记
- This PAK1/2/3 antibody is un-conjugated
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应用范围
- Immunohistochemistry (IHC), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Flow Cytometry (FACS)
- 交叉反应
- 人, 小鼠, 大鼠
- 纯化方法
- Purified by Protein A.
- 免疫原
- Synthetic phospho-peptide surrounding S139+S141+S144 of PAK
- 克隆位点
- 9A3
- 亚型
- IgG
- Top Product
- Discover our top product PAK1/2/3 Primary Antibody
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- 应用备注
- WB(1:300-1000), FCM(1:20-100), IF(ICC)(1:50-200), IHC()
- 限制
- 仅限研究用
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- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C for 12 months.
- 有效期
- 12 months
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- 抗原
- PAK1/2/3 (P21-Activated Kinases 1/2/3 (PAK1/2/3))
- 别名
- PAK1, PAK2, PAK3 (PAK1/2/3 产品)
- 别名
- X-PAK1 antibody, XPak1 antibody, pak antibody, pak-1 antibody, pakalpha antibody, p21 protein (Cdc42/Rac)-activated kinase 1 S homeolog antibody, p21 (RAC1) activated kinase 1 antibody, pak1.S antibody, PAK1 antibody
- 背景
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Synonyms: Serine/threonine-protein kinase PAK 1, Alpha-PAK, p21-activated kinase 1, p65-PAK, Serine/threonine-protein kinase PAK 2, Gamma-PAK, PAK65, S6/H4 kinase, p21-activated kinase 2, p58, Serine/threonine-protein kinase PAK 3, Beta-PAK, Oligophrenin-3, p21-activated kinase 3, PAK-1, PAK1, PAK-2, PAK2, PAK-3, PAK3
Background: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development.
- 基因ID
- 5063
- UniProt
- O75914
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