NPC1 抗体
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- 抗原 See all NPC1 抗体
- NPC1 (Niemann-Pick Disease, Type C1 (NPC1))
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 单克隆
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标记
- This NPC1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- 交叉反应
- 人, 小鼠, 大鼠
- 纯化方法
- Purified by Protein A.
- 免疫原
- Synthetic peptide within human NPC1 aa 1250-1270
- 克隆位点
- 1B12
- 亚型
- IgG
- Top Product
- Discover our top product NPC1 Primary Antibody
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anti-Niemann-Pick Disease, Type C1 (NPC1) (AA 34-174) antibody
NPC1 适用: 人 ELISA, WB, IHC, FACS 宿主: 小鼠 Monoclonal 8D10G3 unconjugated
anti-Niemann-Pick Disease, Type C1 (NPC1) (AA 34-174) antibodyNPC1 适用: 人 ELISA, WB, IHC 宿主: 小鼠 Monoclonal 8D10B6 unconjugated
anti-Niemann-Pick Disease, Type C1 (NPC1) (AA 34-174) antibodyNPC1 适用: 人 ELISA, WB, IHC, FACS 宿主: 小鼠 Monoclonal unconjugated
anti-Niemann-Pick Disease, Type C1 (NPC1) (AA 591-620) antibodyNPC1 适用: 人 ELISA, WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Niemann-Pick Disease, Type C1 (NPC1) (AA 23-269) antibodyNPC1 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Niemann-Pick Disease, Type C1 (NPC1) (AA 151-250) antibodyNPC1 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 4H2 unconjugated
anti-Niemann-Pick Disease, Type C1 (NPC1) antibodyNPC1 适用: 人 WB, IHC, IF, IHC (p), IP 宿主: 小鼠 Monoclonal unconjugated
anti-Niemann-Pick Disease, Type C1 (NPC1) (AA 1230-1278) antibodyNPC1 适用: 人, 小鼠, Hamster WB, IHC, IF, IP, IEM 宿主: 兔 Polyclonal unconjugated
anti-Niemann-Pick Disease, Type C1 (NPC1) (AA 591-620) antibodyNPC1 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB33297 unconjugated
anti-Niemann-Pick Disease, Type C1 (NPC1) (Internal Region) antibodyVerified NPC1 适用: 人 ELISA, WB 宿主: 山羊 Polyclonal unconjugated
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- 应用备注
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WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- NPC1 (Niemann-Pick Disease, Type C1 (NPC1))
- 别名
- NPC1 (NPC1 产品)
- 别名
- NPC antibody, 9130221N23Rik antibody, Gm243 antibody, Cdig2 antibody, im:7149020 antibody, wu:fb53a12 antibody, wu:fc29a12 antibody, A430089E03Rik antibody, C85354 antibody, D18Ertd139e antibody, D18Ertd723e antibody, lcsd antibody, nmf164 antibody, spm antibody, NPC intracellular cholesterol transporter 1 antibody, NPC1 like intracellular cholesterol transporter 1 antibody, Niemann-Pick disease, type C1 antibody, Niemann-Pick C1 protein antibody, NPC1 antibody, Npc1l1 antibody, Npc1 antibody, npc1 antibody, LOC579887 antibody
- 背景
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Synonyms: NPC intracellular cholesterol transporter 1, Niemann Pick C1 protein, NPC1, POGZ, SLC65A1
Background: Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket. Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable). Acts as an endosomal entry receptor for ebolavirus.
- 基因ID
- 4864
- UniProt
- O15118
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