STAT6 抗体
Quick Overview for STAT6 抗体 (ABIN6940672)
抗原
See all STAT6 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
- Purified by Protein A/G
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免疫原
- Recombinant full-length human STAT6 protein
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亚型
- IgG1 kappa
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anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (AA 694-801) antibody
STAT6 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 6C10 unconjugated
anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (AA 614-663) antibodySTAT6 适用: 人, 小鼠, 大鼠, 犬, Cow, 兔, 猴, Pig, 马, 豚鼠, Bat, Hamster WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (pThr645) antibodySTAT6 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IP, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (AA 1-180) antibodySTAT6 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (C-Term) antibodySTAT6 适用: 人, 小鼠, 大鼠, 犬, Cow, 兔, 马, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (pTyr641) antibodySTAT6 适用: 人, 小鼠, 大鼠 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) antibodySTAT6 适用: 人, 小鼠 WB, IHC, IHC (p), FACS, IF (cc) 宿主: 兔 Monoclonal 9A7 unconjugated
anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (AA 557-841) antibodySTAT6 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (AA 1-847) antibodySTAT6 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (AA 694-801) antibodySTAT6 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4G7 unconjugated
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应用备注
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Positive Control: HeLa or HepG2 cells. Kidney.
Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- STAT6 (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))
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别名
- STAT6
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背景
- STAT6 is a transcription factor in the Jak/STAT signal transduction pathway responsible for mediating IL-4 immune signaling. STAT6 was recently suggested to be a reliable marker to distinguish solitary fibrous tumors from other soft tissue neoplasms. Gene fusions are common in solitary fibrous tumors. Recent next generation sequencing studies demonstrated the presence of a NAB2-STAT6 fusion, formed by an intrachromosomal inversion fusing two neighboring genes on chromosome 12q13, in 55-100 % of solitary fibrous tumors, regardless of tumor morphology or anatomical site. By immunohistochemistry, nuclear STAT6 expression can discriminate solitary fibrous tumors from its morphological mimics in the meninges, including meningioma, glioblastoma, gliosarcoma, haemangioblastoma, schwannoma and haemangioma. A recent study by Cheah, et al. using the rabbit monoclonal STAT6 antibody (Clone YE361) observed expression in all solitary fibrous tumors (54/54) tested, regardless of histology, anatomical site or CD34 status. Morphological mimics of solitary fibrous tumors were negative, demonstrating 100 % specificity.
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分子量
- 119kDa
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基因ID
- 6778
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UniProt
- P42226
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途径
- JAK/STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
抗原
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