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Syncytin A (SYNA) (AA 451-538) 抗体

SYNA 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN682318
发货至: 中国
  • 抗原 See all Syncytin A (SYNA) 抗体
    Syncytin A (SYNA)
    抗原表位
    • 2
    • 1
    AA 451-538
    适用
    • 15
    • 5
    • 3
    人, 小鼠
    宿主
    • 18
    克隆类型
    • 18
    多克隆
    标记
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    非结合性
    应用范围
    • 18
    • 8
    • 6
    • 3
    Western Blotting (WB), ELISA
    交叉反应
    人, 小鼠
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human Syncytin 1
    亚型
    IgG
  • 应用备注
    WB 1:300-5000
    ELISA 1:500-1000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    有效期
    12 months
  • Díaz-Carballo, Acikelli, Klein, Jastrow, Dammann, Wyganowski, Guemues, Gustmann, Bardenheuer, Malak, Tefett, Khosrawipour, Giger-Pabst, Tannapfel, Strumberg: "Therapeutic potential of antiviral drugs targeting chemorefractory colorectal adenocarcinoma cells overexpressing endogenous retroviral elements." in: Journal of experimental & clinical cancer research : CR, Vol. 34, pp. 81, (2015) (PubMed).

  • 抗原
    Syncytin A (SYNA)
    别名
    Syncytin 1 (SYNA 产品)
    别名
    Gm453 antibody, Gm52 antibody, syncytin-A antibody, syncytin a antibody, Syna antibody
    背景

    Synonyms: ENV, ENVW, HERVW, ERVWE1, HERV7Q, HERV-7q, HERVWENV, HERV-W-ENV, Syncytin-1, Endogenous retrovirus group W member 1, Env-W, Envelope polyprotein gPr73, Enverin, HERV-7q Envelope protein, HERV-W envelope protein, HERV-W_7q21.2 provirus ancestral Env polyprotein, Syncytin, ERVW-1

    Background: This endogenous retroviral envelope protein has retained its original fusogenic properties and participates in trophoblast fusion and the formation of a syncytium during placenta morphogenesis. May induce fusion through binding of SLC1A4 and SLC1A5 (PubMed:10708449, PubMed:12050356, PubMed:23492904). Endogenous envelope proteins may have kept, lost or modified their original function during evolution. Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. The surface protein (SU) mediates receptor recognition, while the transmembrane protein (TM) acts as a class I viral fusion protein. The protein may have at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of membranes.

    基因ID
    30816
    UniProt
    Q9UQF0
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