TAF1 抗体 (AA 501-600)

Synonyms: TBP Associated Factor 1, BA2R, CCG 1, CCG1, CCGS, Cell cycle G1 phase defect, Cell cycle gene 1 protein, Complementation of cell cycle block G1 to S, DYT3 protein, NSCL 2, NSCL2, OF, p250, TAF 1, TAF 2A, TAFII250, TAF1, TAF1 RNA polymerase II TATA box binding protein TBP associated factor 250 kDa, TAF1 RNA polymerase II TATA box binding protein TBP associated factor, TAF1 RNA polymerase II TATA box binding protein associated factor 250 kDa, TAF1_HUMAN, TAF2A, TAFII 250, TAFII-250, TAFII250, TAF II P250, TATA box binding protein TBP associated factor RNA polymerase II A, TATA box binding protein TBP associated factor RNA polymerase II A 250kD, TBP associated factor 250 kDa, TBP-associated factor 250 kDa, Transcription factor TFIID p250 polypeptide, Transcription initiation factor TFIID 250 kDa subunit, Transcription initiation factor TFIID subunit 1.

Background: Largest component and core scaffold of the TFIID basal transcription factor complex. Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors. Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53. Phosphorylates GTF2A1 and GTF2F1 on Ser residues. Possesses DNA-binding activity. Essential for progression of the G1 phase of the cell cycle.