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NFKB1 抗体 (AA 51-100)

NFKB1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN673194
发货至: 中国
  • 抗原 See all NFKB1 抗体
    NFKB1 (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 1 (NFKB1))
    抗原表位
    • 35
    • 29
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    • 16
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    • 1
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    AA 51-100
    适用
    • 321
    • 176
    • 153
    • 11
    • 8
    • 7
    • 7
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
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    • 1
    人, 小鼠, 大鼠
    宿主
    • 318
    • 21
    • 1
    • 1
    克隆类型
    • 313
    • 28
    多克隆
    标记
    • 141
    • 21
    • 16
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    • 16
    • 16
    • 15
    • 12
    • 9
    • 9
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    • 9
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    • 2
    This NFKB1 antibody is un-conjugated
    应用范围
    • 180
    • 117
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    • 104
    • 103
    • 68
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    • 36
    • 27
    • 14
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    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    交叉反应
    人, 小鼠, 大鼠
    预测反应
    Dog,Cow,Pig,Chicken
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human NFKB1
    亚型
    IgG
    Top Product
    Discover our top product NFKB1 Primary Antibody
  • 应用备注
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    有效期
    12 months
  • 抗原
    NFKB1 (Nuclear Factor of kappa Light Polypeptide Gene Enhancer in B-Cells 1 (NFKB1))
    别名
    NFkB p105 / p50 (NFKB1 产品)
    别名
    GKLP antibody, NKTL antibody, NTKL antibody, P105 antibody, TAPK antibody, TEIF antibody, TRAP antibody, EBP-1 antibody, KBF1 antibody, NF-kB1 antibody, NF-kappa-B antibody, NF-kappaB antibody, NFKB-p105 antibody, NFKB-p50 antibody, NFkappaB antibody, p105 antibody, p50 antibody, NF-kB antibody, NF-KB1 antibody, ebp-1 antibody, kbf1 antibody, nf-kappa-b antibody, nf-kappaB antibody, nfkb-p105 antibody, nfkb-p50 antibody, NF-kappaB1 antibody, p50/p105 antibody, BICDR-1 antibody, bicdr1 antibody, ccdc64 antibody, SCY1 like pseudokinase 1 antibody, nuclear factor kappa B subunit 1 antibody, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 L homeolog antibody, nuclear factor NF-kappa-B p105 subunit antibody, nucleoporin 107 antibody, nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 antibody, nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 antibody, SCYL1 antibody, NFKB1 antibody, Nfkb1 antibody, nfkb1.L antibody, CpipJ_CPIJ012236 antibody, Nup107 antibody, nfkb1 antibody
    背景

    Synonyms: p50, KBF1, p105, EBP-1, NF-kB1, NFKB-p50, NFkappaB, NF-kappaB, NFKB-p105, NF-kappa-B, Nuclear factor NF-kappa-B p105 subunit, DNA-binding factor KBF1, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, NFKB1

    Background: NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and RelB-p50 complexes are transcriptional activators. The NF-kappa-B p50-p50 homodimer is a transcriptional repressor, but can act as a transcriptional activator when associated with BCL3. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. The proteasome-mediated process ensures the production of both p50 and p105 and preserves their independent function, although processing of NFKB1/p105 also appears to occur post-translationally.

    基因ID
    4790
    UniProt
    P19838
    途径
    p53 Pathway, NF-kappaB Signaling, RTK signaling, TCR Signaling, TLR signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Toll-Like Receptors Cascades, BCR Signaling, S100 Proteins
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