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SCN1A 抗体 (C-Term)

SCN1A 适用: 大鼠 IHC, WB, IP, FM 宿主: 小鼠 Monoclonal S74-71 unconjugated
产品编号 ABIN6658122
发货至: 中国
  • 抗原 See all SCN1A 抗体
    SCN1A (Sodium Channel, Voltage-Gated, Type I, alpha Subunit (SCN1A))
    抗原表位
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    适用
    • 26
    • 17
    • 8
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    大鼠
    宿主
    • 24
    • 2
    • 1
    小鼠
    克隆类型
    • 25
    • 2
    单克隆
    标记
    • 16
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SCN1A antibody is un-conjugated
    应用范围
    • 11
    • 10
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Western Blotting (WB), Immunoprecipitation (IP), Fluorescence Microscopy (FM)
    交叉反应
    人, 小鼠, 大鼠
    纯化方法
    Anti-Nav1.1 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with Nav1.1 from Mouse, Human, and Rat based on 100% homology with the immunizing sequence. No cross reactivity against Nav1.2, Nav1.3 and Nav1.6. Cross-reactivity with Nav1.1 from other sources has not been determined. Ion Channels research.
    免疫原

    Immunogen: Nav1.1 Antibody was produced in mice by repeated immunizations raised against a fusion protein corresponding to the cytoplasmic C-terminus region of rat Nav1.1.

    Immunogen Type: Recombinant Protein

    克隆位点
    S74-71
    亚型
    IgG1
    Top Product
    Discover our top product SCN1A Primary Antibody
  • 应用备注

    Immunohistochemistry Dilution: 0.1-1.0 μg/mL

    Application Note: Anti-Nav1.1 Antibody is suitable for use in WB, IP, and IHC. Expect a band approximately ~220 kDa on specific lysates. Epitope mapped within amino acids 690-715. Specific conditions for reactivity should be optimized by the end user.

    Immunoprecipitation Dilution: User Optimized

    Western Blot Dilution: 1 μg/mL

    IF Microscopy Dilution: 1.0-10 μg/mL

    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液

    Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

    Stabilizer: 50 % (v/v) Glycerol

    储存条件
    RT,4 °C,-20 °C
    储存方法
    Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
  • 抗原
    SCN1A (Sodium Channel, Voltage-Gated, Type I, alpha Subunit (SCN1A))
    别名
    Nav1.1 (SCN1A 产品)
    别名
    SCN9A antibody, SCN1A antibody, B230332M13 antibody, Nav1.1 antibody, EIEE6 antibody, FEB3 antibody, FEB3A antibody, FHM3 antibody, GEFSP2 antibody, HBSCI antibody, NAC1 antibody, SCN1 antibody, SMEI antibody, sodium voltage-gated channel alpha subunit 1 antibody, sodium voltage-gated channel alpha subunit 9 antibody, sodium channel, voltage-gated, type I, alpha antibody, SCN1A antibody, SCN9A antibody, Scn1a antibody
    背景

    Synonyms: FEB3, Scn1a, GEFSP2, HBSCI, SCN1, Sodium channel 3

    Background: Voltage gated sodium channels initiate action potentials in neurons. Nav1.1 is abundant in the adult brain, and primarily localized in cell bodies. Mutations in the Nav1.1 channels cause generalized epilepsy with febrile seizures plus (GEFS+). Studies show that Nav1.1 channels also play a crucial role in the excitability of cerebellar Purkinje neurons, with major contributions to peak, persistent and resurgent forms of sodium current and to sustained action potential firing.

    Gene Name: Scn1a

    基因ID
    20265
    NCBI登录号
    NP_061203
    UniProt
    Q62206
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