GPR3 抗体 (G Protein-Coupled Receptor 3) (C-Term)

Details for Product anti-GPR3 Antibody No. ABIN6656714
抗原
  • GPR3
  • ACCA
  • Gpcr3
  • Gpcr20
  • Gpcr21
  • G protein-coupled receptor 3
  • G-protein coupled receptor 3
  • GPR3
  • Gpr3
抗原表位
C-Term
18
9
8
6
5
4
3
2
2
2
1
1
适用

96
45
43
5
3
3
2
2
2
2
2
1
1
1
宿主

83
9
7
克隆类型
多克隆
标记
This GPR3 antibody is un-conjugated
5
4
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
应用范围
ELISA, Fluorescence Microscopy (FM), Immunohistochemistry (IHC), Western Blotting (WB)
46
42
32
29
13
4
3
2
1
1
1
1
选项
免疫原

Immunogen: Anti-GPR3 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 13 amino acid synthetic peptide from near the C-terminus of human GPR3.

Immunogen Type: Peptide

亚型 IgG
交叉反应 人, 小鼠, 大鼠
交叉反应 (详细) Cross reactivity with GPR3 from other sources has not been determined.
纯化方法 Anti-GPR3 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography.
Plasmids, Primers & others Plasmids, Primers & others GPR3 products on genomics-online (e.g. as negative or positive controls)
抗原
别名 GPR3 (GPR3 Antibody 摘要)
背景

Synonyms: GPR3 Antibody, ACCA, ACCA, G-protein coupled receptor 3, ACCA orphan receptor

Background: GPR3, also known as ACCA, is a G-protein coupled receptor that constitutively activates adenylate cyclase and is highly expressed in the central nervous system. Overexpression of GPR3 stimulates the production of amyloid-beta peptide (Abeta), the deposition of which is one of the pathological hallmarks of Alzheimer 's disease (AD), while the ablation of GPR3 prevented the accumulation of Abeta in vitro and in an AD mouse model. This is of particular interest because of the proximity of a reported candidate Alzheimer 's disease (AD) locus, suggesting that GPR3 may be a potential therapeutic target for the treatment of AD. GPR3 has also been shown to block the proliferation of cerebellar granule cell precursors (GCP) during postnatal development by inhibiting the Shh-induced proliferation of GCP, indicating that GPR3 activation may represent one of the signals that triggers the postnatal cell cycle exit and terminal differentiation of GPCs.

Gene Name: GPR3

基因ID 2827
UniProt P46089
途径 cAMP Metabolic Process
应用备注

Immunohistochemistry Dilution: 2.5 μg/mL

Application Note: Anti-GPR3 Antibody has been tested for use in ELISA, Western Blotting, Immunohistochemistry and Immunofluorescence. Specific conditions for reactivity should be optimized by the end user. Expect a band at approximately 35 kDa in Western Blots of specific cell lysates and tissues.

ELISA Dilution: 1:10,000-1:20,000

Western Blot Dilution: 1-2 μg/mL

IF Microscopy Dilution: 20 μg/mL

限制 仅限研究用
状态 Liquid
缓冲液

Buffer: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2

Stabilizer: None

储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件 RT,4 °C,-20 °C
储存方法 Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
厂商提供的图像
Image no. 1 for anti-G Protein-Coupled Receptor 3 (GPR3) (C-Term) antibody (ABIN6656714) Western Blot of GPR3 Antibody - Western Blot of GPR3 antibody. Lane 1: EL4 cell lysat...
Image no. 2 for anti-G Protein-Coupled Receptor 3 (GPR3) (C-Term) antibody (ABIN6656714) Immunofluorescence of GPR3 Antibody Immunofluorescence Microscopy of GPR3 antibody. T...
Image no. 3 for anti-G Protein-Coupled Receptor 3 (GPR3) (C-Term) antibody (ABIN6656714) Immunohistochemistry of GPR3 Antibody - Immunohistochemistry of GPR3 antibody. Tissue...
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