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JunD 抗体 (Ser255)

JUND 适用: 人, 小鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN197142
发货至: 中国
  • 抗原 See all JunD (JUND) 抗体
    JunD (JUND) (Jun D Proto-Oncogene (JUND))
    抗原表位
    • 38
    • 15
    • 9
    • 8
    • 8
    • 8
    • 7
    • 5
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Ser255
    适用
    • 95
    • 60
    • 47
    • 8
    • 7
    • 6
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠
    宿主
    • 115
    • 1
    • 1
    • 1
    克隆类型
    • 105
    • 13
    多克隆
    标记
    • 49
    • 10
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This JunD antibody is un-conjugated
    应用范围
    • 85
    • 39
    • 28
    • 26
    • 26
    • 24
    • 12
    • 12
    • 9
    • 6
    • 6
    • 4
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    特异性
    JunD antibody detects endogenous levels of total JunD protein.
    纯化方法
    Affinity-chromatography using epitope-specific immunogen
    免疫原
    Synthetic non-phosphopeptide derived from human JunD around the phosphorylation site of serine 255 (G-E-Sp-P-P).
    Top Product
    Discover our top product JUND Primary Antibody
  • 应用备注
    Western Blot: 1: 500approx. 1: 1000. Immunohistochemistry: 1: 50approx. 1: 100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    PBS( without Mg2+ and Ca2+), pH 7.4 containing 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    -20 °C
  • 抗原
    JunD (JUND) (Jun D Proto-Oncogene (JUND))
    别名
    Jun-D (JUND 产品)
    别名
    si:dkey-251j8.3 antibody, AP-1 antibody, Jund1 antibody, JunD proto-oncogene, AP-1 transcription factor subunit antibody, jun D proto-oncogene S homeolog antibody, jun D proto-oncogene antibody, jund antibody, jund.S antibody, JUND antibody, Jund antibody
    背景
    JunD is the most broadly expressed member of the Jun family and the AP1 transcription factor complex. It has been found that primary fibroblasts lacking murine JunD displayed p53-dependent growth arrest, upregulated p19(ARF) expression, and premature senescence. In contrast, immortalized cell lines lacking JunD showed increased proliferation and higher cyclin D1 levels. These properties were reminiscent of the effects of oncogenic RAS expression on primary and established cell cultures. Furthermore, JunD -/- fibroblasts exhibited increased p53-dependent apoptosis upon ultraviolet irradiation and were sensitive to the cytotoxic effects of tumor necrosis factor-alpha. The antiapoptotic role of JunD was confirmed using an in vivo model of TNF-mediated hepatitis. The authors proposed that JunD protects cells from senescence, or apoptotic responses to stress stimuli, by acting as a modulator of the signaling pathways that link RAS to p53.Synonyms: JUND, Transcription factor jun-D
    基因ID
    3727
    NCBI登录号
    NP_005345
    UniProt
    P17535
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