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STRA13 抗体

STRA13 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6572068
发货至: 中国
  • 抗原 See all STRA13 抗体
    STRA13 (Stimulated By Retinoic Acid 13 Homolog (STRA13))
    适用
    宿主
    • 7
    克隆类型
    • 7
    多克隆
    标记
    • 4
    • 1
    • 1
    • 1
    This STRA13 antibody is un-conjugated
    应用范围
    • 4
    • 3
    • 1
    Western Blotting (WB)
    纯化方法
    Affinity purification
    免疫原
    Recombinant fusion protein of human STRA13 (NP_659435.2).
    亚型
    IgG
    Top Product
    Discover our top product STRA13 Primary Antibody
  • 应用备注
    WB 1:500-1:2000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    STRA13 (Stimulated By Retinoic Acid 13 Homolog (STRA13))
    别名
    STRA13 (STRA13 产品)
    别名
    CENP-X antibody, CENPX antibody, D9 antibody, FAAP10 antibody, MHF2 antibody, BHLHB2 antibody, centromere protein X antibody, CENPX antibody, Cenpx antibody
    背景
    DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks (PubMed:20347428, PubMed:20347429). In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure.
    分子量

    Observed_MW: 14kDa

    Calculated_MW: 6kDa/7kDa/8kDa

    基因ID
    201254
    UniProt
    A8MT69
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