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IL12RB1 抗体

IL12RB1 适用: 人, 小鼠 IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6568961
发货至: 中国
  • 抗原 See all IL12RB1 抗体
    IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))
    适用
    • 42
    • 24
    • 24
    人, 小鼠
    宿主
    • 57
    • 5
    • 2
    克隆类型
    • 60
    • 4
    多克隆
    标记
    • 25
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IL12RB1 antibody is un-conjugated
    应用范围
    • 44
    • 13
    • 13
    • 12
    • 8
    • 8
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Immunofluorescence (IF)
    纯化方法
    Affinity purification
    免疫原
    Recombinant fusion protein of human IL12RB1 (NP_714912.1).
    亚型
    IgG
    Top Product
    Discover our top product IL12RB1 Primary Antibody
  • 应用备注
    IF 1:10-1:100
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))
    别名
    IL12RB1 (IL12RB1 产品)
    别名
    Il12rb antibody, IL12RB1 antibody, IL-12R antibody, CD212 antibody, IL-12R-BETA1 antibody, IL12RB antibody, IL-12R[b] antibody, interleukin 12 receptor subunit beta 1 antibody, interleukin 12 receptor, beta 1 antibody, Il12rb1 antibody, IL12RB1 antibody
    背景
    The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants.
    分子量

    Observed_MW: 73kDa

    Calculated_MW: 42kDa/72kDa/73kDa

    基因ID
    3594
    UniProt
    P42701
    途径
    JAK/STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
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