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PRKAR1A 抗体

PRKAR1A 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6566690
发货至: 中国
  • 抗原 See all PRKAR1A 抗体
    PRKAR1A (Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A))
    适用
    • 47
    • 18
    • 16
    • 5
    • 4
    • 4
    • 4
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    • 3
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    • 2
    • 2
    • 2
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    宿主
    • 43
    • 4
    克隆类型
    • 44
    • 3
    多克隆
    标记
    • 30
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
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    This PRKAR1A antibody is un-conjugated
    应用范围
    • 40
    • 18
    • 17
    • 6
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    纯化方法
    Affinity purification
    免疫原
    Recombinant protein of human PRKAR1A
    亚型
    IgG
    Top Product
    Discover our top product PRKAR1A Primary Antibody
  • 应用备注
    WB 1:500 - 1:2000 IHC 1:50 - 1:200
    限制
    仅限研究用
  • 浓度
    1 mg/mL
    缓冲液
    Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    PRKAR1A (Protein Kinase, CAMP-Dependent, Regulatory, Type I, alpha (Tissue Specific Extinguisher 1) (PRKAR1A))
    别名
    PRKAR1A (PRKAR1A 产品)
    别名
    ACRDYS1 antibody, ADOHR antibody, CAR antibody, CNC antibody, CNC1 antibody, PKR1 antibody, PPNAD1 antibody, PRKAR1 antibody, TSE1 antibody, 1300018C22Rik antibody, RIalpha antibody, Tse-1 antibody, Tse1 antibody, RIIA antibody, prkar1a antibody, zgc:92515 antibody, im:7047729 antibody, cnc1 antibody, pkr1 antibody, ppnad1 antibody, prkar1 antibody, tse1 antibody, protein kinase cAMP-dependent type I regulatory subunit alpha antibody, protein kinase, cAMP dependent regulatory, type I, alpha antibody, protein kinase cAMP-dependent type 1 regulatory subunit alpha antibody, protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a antibody, cAMP-dependent protein kinase type I-alpha regulatory subunit pseudogene antibody, protein kinase cAMP-dependent type I regulatory subunit alpha S homeolog antibody, PRKAR1A antibody, Prkar1a antibody, prkar1aa antibody, LOC707275 antibody, prkar1a.S antibody
    背景

    Synonyms: ACRDYS1,ADOHR,cAMP dependent protein kinase regulatory subunit alpha 1,cAMP dependent protein kinase regulatory subunit RIalpha,cAMP dependent protein kinase type I alpha regulatory chain,cAMP dependent protein kinase type I alpha regulatory subunit,cAMP-dependent protein kinase type I-alpha regulatory subunit,CAR,Carney complex type 1,CNC 1,CNC,CNC1,DKFZp779L0468,KAP0,MGC17251,PKA RIA,PKR 1,PKR1,PPNAD 1,PPNAD1,PRKAR 1,PRKAR1,PRKAR1A,PRKAR1A/RARA FUSION GENE,Protein kinase A type 1a regulatory subunit,Protein kinase cAMP dependent regulatory type I alpha,PTC2 CHIMERIC ONCOGENE,INCLUDED,Tissue specific extinguisher 1,Tissue-specific extinguisher 1,TSE 1,TSE1

    Background: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed.

    分子量

    Observed_MW: 45kDa

    Calculated_MW: 38kDa/42kDa

    基因ID
    5573
    UniProt
    P10644
    途径
    Hedgehog Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma
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