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CD40 抗体

CD40 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6566508
发货至: 中国
  • 抗原 See all CD40 抗体
    CD40
    适用
    • 187
    • 97
    • 20
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    • 7
    • 6
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
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    • 1
    人, 小鼠, 大鼠
    宿主
    • 103
    • 99
    • 43
    • 3
    • 1
    • 1
    • 1
    克隆类型
    • 155
    • 89
    • 5
    多克隆
    标记
    • 118
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    • 1
    • 1
    • 1
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    This CD40 antibody is un-conjugated
    应用范围
    • 144
    • 91
    • 61
    • 50
    • 30
    • 27
    • 19
    • 18
    • 17
    • 14
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    • 5
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    Western Blotting (WB)
    纯化方法
    Affinity purification
    免疫原
    Recombinant protein of human CD40
    亚型
    IgG
    Top Product
    Discover our top product CD40 Primary Antibody
  • 应用备注
    WB 1:500 - 1:2000
    限制
    仅限研究用
  • 浓度
    1 mg/mL
    缓冲液
    PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    CD40
    别名
    CD40 (CD40 产品)
    别名
    Bp50 antibody, CDW40 antibody, TNFRSF5 antibody, p50 antibody, AI326936 antibody, GP39 antibody, HIGM1 antibody, IGM antibody, IMD3 antibody, T-BAM antibody, TRAP antibody, Tnfrsf5 antibody, TNFSF5 antibody, CD40 molecule antibody, CD40 antigen antibody, CD40 antibody, Cd40 antibody
    背景

    Synonyms: AI326936,B cell associated molecule CD40,B cell surface antigen CD40,B cell-associated molecule,B-cell surface antigen CD40,Bp50,CD 40,CD40,CD40 antigen (TNF receptor superfamily member 5),CD40 antigen,CD40 Molecule,CD40 Molecule,TNF receptor superfamily member 5,CD40 protein,CD40 type II isoform,CD40L receptor,CDw40,GP39,HIGM1,IGM,IMD3,MGC9013,Nerve growth factor receptor related B lymphocyte activation molecule,OTTHUMP00000031699,OTTHUMP00000031700,p50,T-BAM,TBAM,TNF receptor superfamily member 5,TNFRSF5,TNR5,TRAP,Tumor necrosis factor receptor superfamily,member 5,Tumor necrosis factor receptor superfamily member 5,Tumor necrosis factor receptor superfamily member 5 precursor,Tumor necrosis factor receptor superfamily,member 5,isoform CRA_a

    Background: This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

    分子量

    Observed_MW: 42kDa

    Calculated_MW: 22kDa/30kDa

    基因ID
    958
    UniProt
    P25942
    途径
    NF-kappaB Signaling, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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