PI3K p85/p55 抗体 (pTyr199, pTyr467)
PI3K p85/p55
适用: 人, 小鼠, 大鼠, 猴
ELISA, IF, WB, IHC (p)
宿主: 兔
Polyclonal
unconjugated
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- 抗原 See all PI3K p85/p55 products
- PI3K p85/p55 (Phosphoinositide 3 Kinase, p85/p55 (PI3K p85/p55))
- 抗原表位
- AA 410-490, pTyr199, pTyr467
- 适用
- 人, 小鼠, 大鼠, 猴
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PI3K p85/p55 antibody is un-conjugated
- 应用范围
- ELISA, Immunofluorescence (IF), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 原理
- PI 3-kinase p85/p55 is a protein encoded by the PIK3R1 gene which is approximately 83,5 kDa. PI 3-kinase p85/p55 is localised to the cytoplasm, nucleus and cis-Golgi network. It is involved in RET signalling, IL-2 pathway, downstream signalling of activated FGFR2, regulation of lipid metabolism and insulin signalling-generic cascades. PI 3-Kinases are a family of lipid kinases capable of phosphorylating the 3'OH of the inositol ring of phosphoinositides. They are responsible for coordinating a diverse range of cell functions including proliferation and survival. PI 3-kinase p85/p55 is expressed in the nervous system, muscle, liver, heart and kidney. Mutations in the PIK3R1 gene may result in Agammaglobulinemia and SHORT syndrome. STJ90384 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous PI 3-kinase p85/p55 protein which only binds about Y467/199 when Y467/199 is phosphorylated.
- 特异性
- Phospho-PI 3-kinase p85/p55 (Y467/199) Polyclonal Antibody detects endogenous levels of PI 3-kinase p85/p55 protein only when phosphorylated at Y467/199.
- 产品特性
- Rabbit polyclonal to Phospho-PI 3-kinase p85/p55 (Y467/199).
- 纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- 免疫原
- Synthesized peptide derived from human PI 3-kinase p85/p55 around the phosphorylation site of Y467/199.
- 亚型
- IgG
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anti-Phosphoinositide 3 Kinase, p85/p55 (PI3K p85/p55) (pTyr199), (pTyr467) antibody
PI3K p85/p55 适用: 人, 小鼠, 大鼠, 猴 ELISA, IF, WB, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:10000 - 说明
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Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level).
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C, and avoid repeat freeze-thaw cycles.
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- 抗原
- PI3K p85/p55 (Phosphoinositide 3 Kinase, p85/p55 (PI3K p85/p55))
- 别名
- PI 3-kinase p85/p55 (PI3K p85/p55 产品)
- 分子量
- 54/83 kDa
- 基因ID
- 5295
- UniProt
- P27986
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