RNF2 抗体 (Internal Region)
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- 抗原 See all RNF2 抗体
- RNF2 (Ring Finger Protein 2 (RNF2))
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抗原表位
- Internal Region
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This RNF2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 特异性
- RNF2 Antibody detects endogenous levels of total RNF2.
- 预测反应
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human RNF2, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product RNF2 Primary Antibody
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anti-Ring Finger Protein 2 (RNF2) (AA 192-290) antibody
RNF2 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 6C2 unconjugated
anti-Ring Finger Protein 2 (RNF2) (AA 192-290) antibodyRNF2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2B6 unconjugated
anti-Ring Finger Protein 2 (RNF2) (AA 1-336) antibodyRNF2 适用: 人 WB, IHC, IF, IP, ChIP 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 2 (RNF2) (AA 164-223) antibodyRNF2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4C1 unconjugated
anti-Ring Finger Protein 2 (RNF2) antibodyRNF2 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 2 (RNF2) antibodyRNF2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Monoclonal 2H12 unconjugated Recombinant Antibody
anti-Ring Finger Protein 2 (RNF2) (Middle Region) antibodyRNF2 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 斑马鱼, 兔, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 2 (RNF2) (AA 198-232) antibodyRNF2 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal RB52337 unconjugated
anti-Ring Finger Protein 2 (RNF2) (AA 1-100) antibodyRNF2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 2 (RNF2) (AA 165-199) antibodyRNF2 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB52402 unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- RNF2 (Ring Finger Protein 2 (RNF2))
- 别名
- RNF2 (RNF2 产品)
- 别名
- BAP-1 antibody, BAP1 antibody, DING antibody, HIPI3 antibody, RING1B antibody, RING2 antibody, AI326319 antibody, AI450156 antibody, AU019207 antibody, Ring1B antibody, dinG antibody, fa19h05 antibody, ring1b antibody, wu:fa19h05 antibody, wz4556 antibody, bap-1 antibody, bap1 antibody, ding antibody, hipi3 antibody, ring2 antibody, ring finger protein 2 antibody, ring finger protein 2 L homeolog antibody, RNF2 antibody, Rnf2 antibody, rnf2 antibody, rnf2.L antibody
- 背景
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Description: E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation (PubMed:15386022, PubMed:16359901, PubMed:25519132, PubMed:21772249, PubMed:25355358, PubMed:26151332). H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation (By similarity). Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:16359901, PubMed:26151332). PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility (PubMed:26151332). E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4 (PubMed:21772249). Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity (Probable). Association with the chromosomal DNA is cell-cycle dependent. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes (By similarity).
Gene: RNF2
- 分子量
- 37kDa
- 基因ID
- 6045
- UniProt
- Q99496
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