PTPRB 抗体 (N-Term)
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- 抗原 See all PTPRB 抗体
- PTPRB (Protein tyrosine Phosphatase, Receptor Type, B (PTPRB))
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抗原表位
- N-Term
- 适用
- 人, 大鼠, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PTPRB antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- 特异性
- PTPRB Antibody detects endogenous levels of total PTPRB.
- 预测反应
- Pig,Rabbit
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human PTPRB, corresponding to a region within N-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product PTPRB Primary Antibody
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- 应用备注
- WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- PTPRB (Protein tyrosine Phosphatase, Receptor Type, B (PTPRB))
- 别名
- PTPRB (PTPRB 产品)
- 别名
- PTPRB antibody, HPTP-BETA antibody, HPTPB antibody, PTPB antibody, R-PTP-BETA antibody, VEPTP antibody, 3230402H02Rik antibody, C130094E24 antibody, Ptpz antibody, Rptpb antibody, VE-PTP antibody, Veptp antibody, protein tyrosine phosphatase, receptor type B antibody, receptor-type tyrosine-protein phosphatase beta antibody, protein tyrosine phosphatase, receptor type, B antibody, PTPRB antibody, LOC100380677 antibody, Ptprb antibody
- 背景
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Description: Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin (By similarity).
Gene: PTPRB
- 分子量
- 224kDa
- 基因ID
- 5787
- UniProt
- P23467
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