PAD4 抗体 (N-Term)
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- 抗原 See all PAD4 (PADI4) 抗体
- PAD4 (PADI4) (Peptidyl Arginine Deiminase, Type IV (PADI4))
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抗原表位
- N-Term
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适用
- 人, 大鼠, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PAD4 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- PADI4 Antibody detects endogenous levels of total PADI4.
- 预测反应
- Rabbit
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human PADI4, corresponding to a region within N-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product PADI4 Primary Antibody
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anti-Peptidyl Arginine Deiminase, Type IV (PADI4) antibody
PADI4 适用: 人 WB, IHC, IF, IHC (p), FACS 宿主: 小鼠 Monoclonal 4H5 unconjugated
anti-Peptidyl Arginine Deiminase, Type IV (PADI4) (Center) antibodyPADI4 适用: 人, 小鼠 WB, IF, ICC, IHC (p), ChIP 宿主: 兔 Polyclonal unconjugated
anti-Peptidyl Arginine Deiminase, Type IV (PADI4) antibodyPADI4 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Peptidyl Arginine Deiminase, Type IV (PADI4) (N-Term) antibodyVerified PADI4 适用: 人 IHC, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Peptidyl Arginine Deiminase, Type IV (PADI4) (AA 374-550) antibodyPADI4 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Peptidyl Arginine Deiminase, Type IV (PADI4) (AA 299-588) antibodyPADI4 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 5E7 unconjugated
anti-Peptidyl Arginine Deiminase, Type IV (PADI4) (AA 1-300) antibodyPADI4 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Peptidyl Arginine Deiminase, Type IV (PADI4) antibodyPADI4 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Peptidyl Arginine Deiminase, Type IV (PADI4) (AA 299-588) antibodyPADI4 适用: 人 WB, FACS 宿主: 小鼠 Monoclonal 5B7 unconjugated
anti-Peptidyl Arginine Deiminase, Type IV (PADI4) (AA 299-588) antibodyPADI4 适用: 人 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 3E1 unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- PAD4 (PADI4) (Peptidyl Arginine Deiminase, Type IV (PADI4))
- 别名
- PADI4 (PADI4 产品)
- 别名
- PAD antibody, PAD4 antibody, PADI5 antibody, PDI4 antibody, PDI5 antibody, Pad4 antibody, Pdi4 antibody, peptidyl arginine deiminase 4 antibody, peptidyl arginine deiminase, type IV antibody, PADI4 antibody, Padi4 antibody
- 背景
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Description: Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1.
Gene: PADI4
- 分子量
- 74kDa
- 基因ID
- 23569
- UniProt
- Q9UM07
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