MPHOSPH8 抗体 (Internal Region)
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- 抗原 See all MPHOSPH8 抗体
- MPHOSPH8 (M-Phase phosphoprotein 8 (MPHOSPH8))
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抗原表位
- Internal Region
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This MPHOSPH8 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 特异性
- MPHOSPH8 Antibody detects endogenous levels of total MPHOSPH8.
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human MPHOSPH8, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product MPHOSPH8 Primary Antibody
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anti-M-Phase phosphoprotein 8 (MPHOSPH8) (AA 1-259) antibody
MPHOSPH8 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
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- 应用备注
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- MPHOSPH8 (M-Phase phosphoprotein 8 (MPHOSPH8))
- 别名
- MPHOSPH8 (MPHOSPH8 产品)
- 别名
- HSMPP8 antibody, TWA3 antibody, mpp8 antibody, 1500035L22Rik antibody, 4930548G07Rik antibody, AU040635 antibody, Ab2-008 antibody, RGD1305133 antibody, M-phase phosphoprotein 8 antibody, MPHOSPH8 antibody, Mphosph8 antibody
- 背景
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Description: Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (PubMed:20871592, PubMed:26022416). Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3 (PubMed:26022416). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites, these can be situated within the coding region of the gene (PubMed:20871592). Mediates down-regulation of CDH1 expression (PubMed:20871592).
Gene: MPHOSPH8
- 分子量
- 97 kDa
- 基因ID
- 54737
- UniProt
- Q99549
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