MICAL1 抗体 (Internal Region)
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- 抗原 See all MICAL1 抗体
- MICAL1 (Microtubule Associated Monoxygenase, Calponin and LIM Domain Containing 1 (MICAL1))
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抗原表位
- Internal Region
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This MICAL1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- MICAL1 Antibody detects endogenous levels of total MICAL1.
- 预测反应
- Pig,Bovine,Horse,Sheep,Dog
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human MICAL1, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product MICAL1 Primary Antibody
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- MICAL1 (Microtubule Associated Monoxygenase, Calponin and LIM Domain Containing 1 (MICAL1))
- 别名
- MICAL1 (MICAL1 产品)
- 别名
- MICAL antibody, MICAL-1 antibody, NICAL antibody, Nical antibody, zgc:171928 antibody, microtubule associated monooxygenase, calponin and LIM domain containing 1 antibody, MICAL1 antibody, Mical1 antibody, mical1 antibody
- 背景
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Description: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (By similarity). In the absence of actin, it also functions as a NADPH oxidase producing H2O2 (PubMed:21864500, PubMed:26845023). Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L, acts by antagonizing STK38 and STK38L activation by MST1/STK4. Involved in regulation of lamina-specific connectivity in the nervous system such as the development of lamina-restricted hippocampal connections. Through redox regulation of the actin cytoskeleton controls the intracellular distribution of secretory vesicles containing L1/neurofascin/NgCAM family proteins in neurons, thereby regulating their cell surface levels (By similarity). May act as Rab effector protein and play a role in vesicle trafficking.
Gene: MICAL1
- 分子量
- 120 kDa
- 基因ID
- 64780
- UniProt
- Q8TDZ2
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