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LAT 抗体 (Internal Region)

LAT 适用: 人, 小鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6262916
发货至: 中国
  • 抗原 See all LAT 抗体
    LAT (Linker For Activation of T Cells (LAT))
    抗原表位
    • 19
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    Internal Region
    适用
    • 124
    • 58
    • 41
    • 1
    • 1
    人, 小鼠
    宿主
    • 116
    • 8
    • 2
    • 1
    克隆类型
    • 118
    • 9
    多克隆
    标记
    • 62
    • 7
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    This LAT antibody is un-conjugated
    应用范围
    • 72
    • 41
    • 39
    • 39
    • 17
    • 11
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    • 9
    • 5
    • 3
    • 1
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    Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
    特异性
    LAT Antibody detects endogenous levels of total LAT.
    预测反应
    Pig,Zebrafish,Bovine,Horse,Sheep
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide derived from human LAT, corresponding to a region within the internal amino acids.
    亚型
    IgG
    Top Product
    Discover our top product LAT Primary Antibody
  • 应用备注
    WB 1:1000-3000, IF/ICC 1:200-1:500, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • 抗原
    LAT (Linker For Activation of T Cells (LAT))
    别名
    LAT (LAT 产品)
    背景

    Description: Required for TCR (T-cell antigen receptor)- and pre-TCR-mediated signaling, both in mature T-cells and during their development. Involved in FCGR3 (low affinity immunoglobulin gamma Fc region receptor III)-mediated signaling in natural killer cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Couples activation of these receptors and their associated kinases with distal intracellular events such as mobilization of intracellular calcium stores, PKC activation, MAPK activation or cytoskeletal reorganization through the recruitment of PLCG1, GRB2, GRAP2, and other signaling molecules.

    Gene: LAT

    分子量
    28kDa
    基因ID
    27040
    UniProt
    O43561
    途径
    TCR Signaling, Fc-epsilon Receptor Signaling Pathway
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