电话:
400-7060-959
传真:
+86 10 56315212-8813
电子邮件:
orders@antibodies-online.cn

IRS4 抗体 (C-Term)

IRS4 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6262669
发货至: 中国
  • 抗原 See all IRS4 抗体
    IRS4 (Insulin Receptor Substrate 4 (IRS4))
    抗原表位
    • 15
    • 15
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    适用
    • 32
    • 21
    • 15
    宿主
    • 35
    • 2
    • 1
    克隆类型
    • 36
    • 2
    多克隆
    标记
    • 10
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This IRS4 antibody is un-conjugated
    应用范围
    • 26
    • 26
    • 21
    • 10
    • 6
    • 6
    • 3
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    特异性
    IRS4 Antibody detects endogenous levels of total IRS4.
    预测反应
    Bovine,Horse,Rabbit
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide derived from human IRS4, corresponding to a region within C-terminal amino acids.
    亚型
    IgG
    Top Product
    Discover our top product IRS4 Primary Antibody
  • 应用备注
    WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • 抗原
    IRS4 (Insulin Receptor Substrate 4 (IRS4))
    别名
    IRS4 (IRS4 产品)
    别名
    IRS4 antibody, irs-4 antibody, py160 antibody, IRS-4 antibody, PY160 antibody, irs2 antibody, irs2-a antibody, insulin receptor substrate 4 antibody, insulin receptor substrate 4 S homeolog antibody, IRS4 antibody, irs4 antibody, Irs4 antibody, irs4.S antibody
    背景

    Description: Acts as an interface between multiple growth factor receptors possessing tyrosine kinase activity, such as insulin receptor, IGF1R and FGFR1, and a complex network of intracellular signaling molecules containing SH2 domains. Involved in the IGF1R mitogenic signaling pathway. Promotes the AKT1 signaling pathway and BAD phosphorylation during insulin stimulation without activation of RPS6KB1 or the inhibition of apoptosis. Interaction with GRB2 enhances insulin-stimulated mitogen-activated protein kinase activity. May be involved in nonreceptor tyrosine kinase signaling in myoblasts. Plays a pivotal role in the proliferation/differentiation of hepatoblastoma cell through EPHB2 activation upon IGF1 stimulation. May play a role in the signal transduction in response to insulin and to a lesser extent in response to IL4 and GH on mitogenesis. Plays a role in growth, reproduction and glucose homeostasis. May act as negative regulators of the IGF1 signaling pathway by suppressing the function of IRS1 and IRS2.

    Gene: IRS4

    分子量
    133 kDa
    基因ID
    8471
    UniProt
    O14654
You are here:
客服