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Cyclin D1 抗体 (C-Term)

Name: Cyclin D1 抗体 (C-Term)
SKU: ABIN6261145
Availability: OutOfStock

CCND1 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

Western blot analysis of Cyclin D1 expression in MCF7 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.

estern blot analysis of Cyclin D1 expression in mouse brain tissue lysates,The lane on the right is treated with the antigen-specific peptide.

IF/ICC

3 images

(10 references)

产品编号 ABIN6261145

发货至: 中国

Datasheet as PDF

抗原 See all Cyclin D1 (CCND1) 抗体

Cyclin D1 (CCND1)
抗原表位
22

21

16

16

13

11

10

9

7

7

7

7

7

6

6

5

3

3

3

3

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
C-Term
适用
242

127

123

38

19

19

17

10

9

8

4

3

3

3

3

2

1

1

1

1

1
人, 大鼠, 小鼠
宿主
210

56

1
兔
Compatible Secondaries
克隆类型
198

67
多克隆
标记
118

29

21

9

8

7

7

7

7

7

7

5

3

3

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1
This Cyclin D1 antibody is un-conjugated
应用范围
203

89

70

66

41

31

27

27

25

21

19

13

6

5

3

2

2

2

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

特异性

Cyclin D1 Antibody detects endogenous levels of total Cyclin D1.

预测反应

Pig,Zebrafish,Bovine,Dog,Chicken,Xenopus

纯化方法

The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

免疫原

A synthesized peptide derived from human Cyclin D1, corresponding to a region within C-terminal amino acids.

亚型

IgG

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anti-Cyclin D1 (CCND1) (C-Term) antibody
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anti-Cyclin D1 (CCND1) (AA 96-295) antibody
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anti-Cyclin D1 (CCND1) antibody
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anti-Cyclin D1 (CCND1) (AA 167-295) antibody
CCND1 适用: 人 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 3B6G3 unconjugated

anti-Cyclin D1 (CCND1) (AA 1-295) antibody
CCND1 适用: 人, 小鼠 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 1F7F5 unconjugated

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anti-Cyclin D1 (CCND1) (AA 68-97) antibody
CCND1 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Cyclin D1 (CCND1) antibody
CCND1 适用: 人, 大鼠, 小鼠, 猴 WB, IHC, FACS, IF, StM 宿主: 小鼠 Monoclonal DCS-6 unconjugated

anti-Cyclin D1 (CCND1) (AA 1-233) antibody
CCND1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

应用备注

WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store at -20 °C. Stable for 12 months from date of receipt.

有效期

12 months
Yuan, Wu, Li, Niu, Tan, Qiu: "Regulation of Signaling Pathways Involved in the Anti-proliferative and Apoptosis-inducing Effects of M22 against Non-small Cell Lung Adenocarcinoma A549 Cells." in: Scientific reports, Vol. 8, Issue 1, pp. 992, (2018) (PubMed).

Li, Liu, Zhang, Cui, Ge, Wang, Chen: "Upregulation of E‑cadherin expression mediated by a novel dsRNA suppresses the growth and metastasis of bladder cancer cells by inhibiting β-catenin/TCF target genes." in: International journal of oncology, Vol. 52, Issue 6, pp. 1815-1826, (2018) (PubMed).

Huang, Song, Tao, Shao, Zeng, Xu, Qi, Sun: "Ovostatin 2 knockdown significantly inhibits the growth, migration, and tumorigenicity of cutaneous malignant melanoma cells." in: PLoS ONE, Vol. 13, Issue 4, pp. e0195610, (2018) (PubMed).

Shen, Yuan, Zhao, Li, Xu, Lou, Zheng, Bu, Guo, Xi: "Novel long non-coding RNA GACAT3 promotes gastric cancer cell proliferation through the IL-6/STAT3 signaling pathway." in: Tumour biology, Vol. 37, Issue 11, pp. 14895-14902, (2017) (PubMed).

Li, Wang, Yu, Wu, Hu, Wang, Ye: "miR-3619-5p inhibits prostate cancer cell growth by activating CDKN1A expression." in: Oncology reports, Vol. 37, Issue 1, pp. 241-248, (2017) (PubMed).

Yuan, Xi, Chen, Zhu, Kang, Zou, Wang, Bu: "STAT3 stimulates adipogenic stem cell proliferation and cooperates with HMGA2 during the early stage of differentiation to promote adipogenesis." in: Biochemical and biophysical research communications, Vol. 482, Issue 4, pp. 1360-1366, (2017) (PubMed).

Li, Chen, Chen, Mo, Li, Xiao, Yu, Guo: "Circular RNA 0000096 affects cell growth and migration in gastric cancer." in: British journal of cancer, Vol. 116, Issue 5, pp. 626-633, (2017) (PubMed).

Zhang, Wang, Miao, Li, Chen, Li: "Enhancing E-cadherin expression via promoter-targeted miR-373 suppresses bladder cancer cells growth and metastasis." in: Oncotarget, Vol. 8, Issue 55, pp. 93969-93983, (2017) (PubMed).

Ge, Wang, Ruan, Chen, Liu, Ye: "Overexpression of p53 activated by small activating RNA suppresses the growth of human prostate cancer cells." in: OncoTargets and therapy, Vol. 9, pp. 231-41, (2016) (PubMed).

Wang, Ge, Zhang, Chen, Hu, Li, Ye: "Targeted p53 activation by saRNA suppresses human bladder cancer cells growth and metastasis." in: Journal of experimental & clinical cancer research : CR, Vol. 35, pp. 53, (2016) (PubMed).
抗原

Cyclin D1 (CCND1)

别名

CCND1 (CCND1 产品)

别名

BCL1 antibody, D11S287E antibody, PRAD1 antibody, U21B31 antibody, AI327039 antibody, CycD1 antibody, Cyl-1 antibody, bcl-1 antibody, cD1 antibody, cb161 antibody, cycd1 antibody, etID37810.7 antibody, fb52e01 antibody, fc45c08 antibody, fc83a12 antibody, id:ibd1198 antibody, wu:fb52e01 antibody, wu:fc45c08 antibody, wu:fc83a12 antibody, ccnd1b antibody, prad1 antibody, ccnd1 antibody, ccnd1a antibody, bcl1 antibody, d11s287e antibody, u21b31 antibody, CCND1 antibody, cyclin D1 antibody, cyclin D1 S homeolog antibody, cyclin D1 L homeolog antibody, CCND1 antibody, Ccnd1 antibody, ccnd1 antibody, ccnd1.S antibody, ccnd1.L antibody

背景

Description: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.
Gene: CCND1

分子量

33kDa

基因ID

595

UniProt

P24385

途径

PI3K-Akt Signaling, Cell Division Cycle, Mitotic G1-G1/S Phases, ER-Nucleus Signaling