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c-MET 抗体 (Internal Region)

MET 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6260340
发货至: 中国
  • 抗原 See all c-MET (MET) 抗体
    c-MET (MET) (Met Proto-Oncogene (MET))
    抗原表位
    • 49
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    Internal Region
    适用
    • 250
    • 143
    • 97
    • 8
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    • 1
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    人, 小鼠, 大鼠
    宿主
    • 221
    • 39
    • 3
    • 2
    克隆类型
    • 209
    • 56
    多克隆
    标记
    • 131
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    This c-MET antibody is un-conjugated
    应用范围
    • 181
    • 104
    • 51
    • 42
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    • 14
    • 8
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    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    特异性
    C-Met Antibody detects endogenous levels of total c-Met.
    预测反应
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide derived from human c-Met, corresponding to a region within the internal amino acids.
    亚型
    IgG
    Top Product
    Discover our top product MET Primary Antibody
  • 应用备注
    WB 1:500-1:2000, IF/ICC 1:100-1:500, IHC 1:200, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • 抗原
    c-MET (MET) (Met Proto-Oncogene (MET))
    别名
    MET (MET 产品)
    别名
    AUTS9 antibody, HGFR antibody, RCCP2 antibody, c-Met antibody, AI838057 antibody, HGF antibody, Par4 antibody, Hgfr antibody, c-met antibody, MET antibody, C-MET antibody, met antibody, met-A antibody, MET proto-oncogene, receptor tyrosine kinase antibody, met proto-oncogene antibody, MET proto-oncogene, receptor tyrosine kinase L homeolog antibody, MET antibody, Met antibody, met.L antibody
    背景

    Description: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis (By similarity).

    Gene: MET

    分子量
    155kDa
    基因ID
    4233
    UniProt
    P08581
    途径
    RTK signaling, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor
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