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- 抗原 See all BRSK2 抗体
- BRSK2 (BR serine/threonine Kinase 2 (BRSK2))
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抗原表位
- Internal Region
- 适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This BRSK2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 特异性
- BRSK2 Antibody detects endogenous levels of total BRSK2.
- 预测反应
- Pig,Bovine,Horse,Dog,Chicken
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human BRSK2, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product BRSK2 Primary Antibody
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anti-BR serine/threonine Kinase 2 (BRSK2) (Internal Region) antibody
Verified BRSK2 适用: 人 ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-BR serine/threonine Kinase 2 (BRSK2) antibodyBRSK2 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-BR serine/threonine Kinase 2 (BRSK2) (AA 1-170) antibodyBRSK2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-BR serine/threonine Kinase 2 (BRSK2) (AA 706-736), (C-Term) antibodyBRSK2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB5548 unconjugated
anti-BR serine/threonine Kinase 2 (BRSK2) (C-Term) antibodyBRSK2 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- BRSK2 (BR serine/threonine Kinase 2 (BRSK2))
- 别名
- BRSK2 (BRSK2 产品)
- 别名
- C11orf7 antibody, PEN11B antibody, SAD1 antibody, SADA antibody, STK29 antibody, BRSK2 antibody, 4833424K13Rik antibody, SAD-A antibody, BR serine/threonine kinase 2 antibody, BRSK2 antibody, Brsk2 antibody
- 背景
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Description: Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress.
Gene: BRSK2
- 分子量
- 82 kDa
- 基因ID
- 9024
- UniProt
- Q8IWQ3
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