Angiopoietin 1 抗体 (Internal Region)
(1 reference)-
- 抗原 See all Angiopoietin 1 (ANGPT1) 抗体
- Angiopoietin 1 (ANGPT1)
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抗原表位
- Internal Region
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Angiopoietin 1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA
- 特异性
- Angiopoietin 1 Antibody detects endogenous levels of total Angiopoietin 1.
- 预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human Angiopoietin 1, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product ANGPT1 Primary Antibody
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anti-Angiopoietin 1 (ANGPT1) (AA 304-450) antibody
ANGPT1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 1 (ANGPT1) (AA 260-400) antibodyANGPT1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 1 (ANGPT1) antibodyANGPT1 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 1 (ANGPT1) (Internal Region) antibodyVerified ANGPT1 适用: 人 WB, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Angiopoietin 1 (ANGPT1) (AA 276-375) antibodyANGPT1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 1 (ANGPT1) (AA 21-228) antibodyANGPT1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 1 (ANGPT1) (AA 284-452) antibodyANGPT1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 1 (ANGPT1) (AA 253-429) antibodyANGPT1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 1 (ANGPT1) (N-Term) antibodyANGPT1 适用: 人, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 1 (ANGPT1) antibodyANGPT1 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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: "[Dose and timing of normal saline resuscitation on endothelial glycocalyx in early septic shock]." in: Zhonghua wei zhong bing ji jiu yi xue, Vol. 30, Issue 7, pp. 629-634, (2018) (PubMed).
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: "[Dose and timing of normal saline resuscitation on endothelial glycocalyx in early septic shock]." in: Zhonghua wei zhong bing ji jiu yi xue, Vol. 30, Issue 7, pp. 629-634, (2018) (PubMed).
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- 抗原
- Angiopoietin 1 (ANGPT1)
- 别名
- ANGPT1 (ANGPT1 产品)
- 背景
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Description: Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.
Gene: ANGPT1
- 分子量
- 57 kDa
- 基因ID
- 284
- UniProt
- Q15389
- 途径
- RTK signaling, Glycosaminoglycan Metabolic Process
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