RIPK1 抗体 (Internal Region)
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- 抗原 See all RIPK1 抗体
- RIPK1 (Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1))
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抗原表位
- Internal Region
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This RIPK1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- 特异性
- RIPK1 Antibody detects endogenous levels of total RIPK1.
- 预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human RIPK1, corresponding to a region within the internal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product RIPK1 Primary Antibody
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anti-Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) (AA 17-289) antibody
RIPK1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) (AA 1-179) antibodyRIPK1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) (AA 133-422) antibodyRIPK1 适用: 人 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2D6 unconjugated
anti-Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) (AA 170-440) antibodyRIPK1 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) (AA 131-277) antibodyRIPK1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3B5B6 unconjugated
anti-Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) (AA 306-449) antibodyRIPK1 适用: 人 WB, IHC (p), IF 宿主: 兔 Polyclonal unconjugated
anti-Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) (AA 1-656) antibodyRIPK1 适用: 小鼠 WB, ELISA, IP 宿主: 兔 Polyclonal unconjugated
anti-Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) (AA 328-458) antibodyRIPK1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) (AA 133-422) antibodyRIPK1 适用: 人, 犬 WB 宿主: 小鼠 Monoclonal 2A8 unconjugated
anti-Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1) (AA 133-422) antibodyRIPK1 适用: 人, 犬 WB 宿主: 小鼠 Monoclonal 1A7 unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 有效期
- 12 months
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- 抗原
- RIPK1 (Receptor (TNFRSF)-Interacting serine-threonine Kinase 1 (RIPK1))
- 别名
- RIPK1 (RIPK1 产品)
- 别名
- RIP antibody, RIP1 antibody, D330015H01Rik antibody, Rinp antibody, Rip1 antibody, rip1 antibody, ripk1 antibody, xRIP1beta antibody, xrip1 antibody, receptor interacting serine/threonine kinase 1 antibody, receptor (TNFRSF)-interacting serine-threonine kinase 1 antibody, receptor interacting serine/threonine kinase 1 L homeolog antibody, RIPK1 antibody, Ripk1 antibody, ripk1.L antibody
- 背景
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Description: Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.
Gene: RIPK1
- 分子量
- 76 kDa
- 基因ID
- 8737
- UniProt
- Q13546
- 途径
- NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, TLR signaling, Activation of Innate immune Response, Inositol Metabolic Process, Positive Regulation of Endopeptidase Activity, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, Negative Regulation of intrinsic apoptotic Signaling, SARS-CoV-2 Protein Interactome, Ubiquitin Proteasome Pathway
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