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Usp30 抗体 (N-Term)

Usp30 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, IHC, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6258562
发货至: 中国
  • 抗原 See all Usp30 抗体
    Usp30 (Ubiquitin Specific Peptidase 30 (Usp30))
    抗原表位
    • 10
    • 8
    • 6
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    N-Term
    适用
    • 34
    • 8
    • 7
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    人, 小鼠, 大鼠
    宿主
    • 33
    • 1
    克隆类型
    • 33
    • 1
    多克隆
    标记
    • 14
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Usp30 antibody is un-conjugated
    应用范围
    • 23
    • 17
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC)
    特异性
    USP30 Antibody detects endogenous levels of total USP30.
    预测反应
    Pig,Bovine,Horse,Sheep,Dog,Chicken
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide derived from human USP30, corresponding to a region within N-terminal amino acids.
    亚型
    IgG
  • 应用备注
    WB 1:500-1:1000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • 抗原
    Usp30 (Ubiquitin Specific Peptidase 30 (Usp30))
    别名
    USP30 (Usp30 产品)
    别名
    6330590F17Rik antibody, AI851327 antibody, D5Ertd483e antibody, si:dkey-72n1.2 antibody, ubiquitin specific peptidase 30 antibody, ubiquitin specific peptidase 30 L homeolog antibody, USP30 antibody, usp30 antibody, usp30.L antibody, Usp30 antibody
    背景

    Description: Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves 'Lys-6'- and 'Lys-11'-linked polyubiquitin chains, 2 types of linkage that participate to mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity).

    Gene: USP30

    分子量
    60 kDa
    基因ID
    84749
    UniProt
    Q70CQ3
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