Mesothelin 抗体 (C-Term)
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- 抗原 See all Mesothelin (MSLN) 抗体
- Mesothelin (MSLN)
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抗原表位
- C-Term
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Mesothelin antibody is un-conjugated
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应用范围
- ELISA, Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
- 特异性
- GPR30 Antibody detects endogenous levels of total GPR30.
- 预测反应
- Pig,Horse,Dog,Chicken
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human GPR30, corresponding to a region within C-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product MSLN Primary Antibody
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anti-Mesothelin (MSLN) (AA 273-407) antibody
MSLN 适用: 人 IHC (f) 宿主: 小鼠 Monoclonal MSLN-2131 unconjugated
anti-Mesothelin (MSLN) (AA 101-200) antibodyMSLN 适用: 人 ELISA, WB, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Mesothelin (MSLN) (AA 296-580) antibodyMSLN 适用: 人 ELISA, FACS 宿主: 兔 Monoclonal DM71 unconjugated Recombinant Antibody
anti-Mesothelin (MSLN) (AA 273-407) antibodyMSLN 适用: 人 IHC (f) 宿主: 小鼠 Monoclonal unconjugated
anti-Mesothelin (MSLN) (AA 37-286) antibodyMSLN 适用: 人, 小鼠 ELISA, WB, FACS 宿主: 小鼠 Monoclonal 5C11A4 unconjugated
anti-Mesothelin (MSLN) (AA 37-598) antibodyMSLN 适用: 人 ELISA, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Mesothelin (MSLN) (AA 273-407) antibody (Biotin)MSLN 适用: 人 IHC (f) 宿主: 小鼠 Monoclonal Biotin
anti-Mesothelin (MSLN) (AA 296-606) antibodyMSLN 适用: 人, 小鼠 ELISA, WB 宿主: 小鼠 Monoclonal 7E6A6 unconjugated
anti-Mesothelin (MSLN) (Extracellular), (Extracellular Domain) antibodyMSLN 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal MB-G10 unconjugated
anti-Mesothelin (MSLN) (Extracellular Domain) antibodyMSLN 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal MN-1 unconjugated
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- 应用备注
- WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 有效期
- 12 months
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- 抗原
- Mesothelin (MSLN)
- 别名
- GPER1 (MSLN 产品)
- 别名
- MPF antibody, SMRP antibody, MSLN antibody, mesothelin antibody, MSLN antibody, Msln antibody, LOC611363 antibody, LOC100524016 antibody
- 背景
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Description: G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells. Functions also as a receptor for aldosterone mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway. Involved in cancer progression regulation. Stimulates cancer-associated fibroblast (CAF) proliferation by a rapid genomic response through the EGFR/ERK transduction pathway. Associated with EGFR, may act as a transcription factor activating growth regulatory genes (c-fos, cyclin D1). Promotes integrin alpha-5/beta-1 and fibronectin (FN) matrix assembly in breast cancer cells.
Gene: GPER1
- 分子量
- 42 kDa
- 基因ID
- 2852
- UniProt
- Q99527
- 途径
- EGFR Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Carbohydrate Homeostasis, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process
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