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CELF1 抗体 (N-Term)

CELF1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6258447
发货至: 中国
  • 抗原 See all CELF1 抗体
    CELF1 (CUGBP, Elav-Like Family Member 1 (CELF1))
    抗原表位
    • 14
    • 8
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    适用
    • 51
    • 22
    • 21
    • 7
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 39
    • 12
    克隆类型
    • 39
    • 12
    多克隆
    标记
    • 27
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This CELF1 antibody is un-conjugated
    应用范围
    • 35
    • 24
    • 19
    • 8
    • 7
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
    特异性
    CELF-1 Antibody detects endogenous levels of total CELF-1.
    预测反应
    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
    纯化方法
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    免疫原
    A synthesized peptide derived from human CELF-1, corresponding to a region within N-terminal amino acids.
    亚型
    IgG
    Top Product
    Discover our top product CELF1 Primary Antibody
  • 应用备注
    WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • 抗原
    CELF1 (CUGBP, Elav-Like Family Member 1 (CELF1))
    别名
    CELF1 (CELF1 产品)
    别名
    CUGBP1 antibody, BRUNOL2 antibody, CUG-BP antibody, CUGBP antibody, EDEN-BP antibody, NAB50 antibody, NAPOR antibody, hNab50 antibody, 1600010O03Rik antibody, AA407467 antibody, Brunol2 antibody, CUG-BP1 antibody, Cugbp1 antibody, D2Wsu101e antibody, HNAB50 antibody, Bruno-like antibody, brul antibody, cb920 antibody, cugbp1 antibody, brunol2 antibody, cug-bp antibody, cug-bp1 antibody, cugbp antibody, cugbp1-a antibody, eden-bp antibody, edenbp antibody, nab50 antibody, CUGBP Elav-like family member 1 antibody, CUGBP, Elav-like family member 1 antibody, cugbp, Elav-like family member 1 antibody, CUGBP Elav-like family member 1 L homeolog antibody, CELF1 antibody, Celf1 antibody, celf1 antibody, celf1.L antibody
    背景

    Description: RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver. May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF2, negatively regulates the processing to mature miRNA (PubMed:28431233).

    Gene: CELF1

    分子量
    52 kDa
    基因ID
    10658
    UniProt
    Q92879
    途径
    Ribonucleoprotein Complex Subunit Organization
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