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TRKA 抗体 (pTyr681, Tyr680)

NTRK1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6256787
发货至: 中国
  • 抗原 See all TRKA (NTRK1) 抗体
    TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))
    抗原表位
    • 36
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    pTyr681, Tyr680
    适用
    • 238
    • 150
    • 143
    • 15
    • 4
    • 4
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 247
    • 15
    • 3
    • 2
    克隆类型
    • 239
    • 27
    • 1
    多克隆
    标记
    • 101
    • 18
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    This TRKA antibody is un-conjugated
    应用范围
    • 184
    • 98
    • 79
    • 78
    • 50
    • 38
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    • 20
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    • 14
    • 8
    • 6
    • 4
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    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    特异性
    Phospho-TrkA (Tyr680+Tyr681) Antibody detects endogenous levels of TrkA only when phosphorylated at Tyrosine 680+Tyrosine 681.
    预测反应
    Pig,Zebrafish,Bovine,Sheep,Rabbit,Dog,Chicken
    纯化方法
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    免疫原
    A synthesized peptide derived from human TrkA around the phosphorylation site of Tyr680+Tyr681.
    亚型
    IgG
  • 应用备注
    WB 1:500-1:2000, IHC 1:50-1:500, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • Liu, Geng, Zhang, Wang, Zhang, Duan, Zhang: "Oligo-Porphyran Ameliorates Neurobehavioral Deficits in Parkinsonian Mice by Regulating the PI3K/Akt/Bcl-2 Pathway." in: Marine drugs, Vol. 16, Issue 3, (2018) (PubMed).

  • 抗原
    TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))
    别名
    NTRK1 (NTRK1 产品)
    别名
    MTC antibody, TRK antibody, TRK1 antibody, TRKA antibody, Trk-A antibody, p140-TrkA antibody, CDHF12 antibody, CDHR16 antibody, HSCR1 antibody, MEN2A antibody, MEN2B antibody, MTC1 antibody, PTC antibody, RET-ELE1 antibody, RET51 antibody, Trk antibody, C80751 antibody, Tkr antibody, TrkA antibody, trk antibody, trka antibody, CTRKA antibody, trkA antibody, neurotrophic receptor tyrosine kinase 1 antibody, ret proto-oncogene antibody, neurotrophic tyrosine kinase, receptor, type 1 antibody, NTRK1 antibody, RET antibody, Ntrk1 antibody, ntrk1 antibody
    背景

    Description: Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand (PubMed:1850821, PubMed:1849459, PubMed:1281417, PubMed:8325889, PubMed:15488758, PubMed:17196528, PubMed:27445338). Can also bind and be activated by NTF3/neurotrophin-3. However, NTF3 only supports axonal extension through NTRK1 but has no effect on neuron survival (By similarity). Upon dimeric NGF ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:1281417). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades driving cell survival and differentiation. Through SHC1 and FRS2 activates a GRB2-Ras-MAPK cascade that regulates cell differentiation and survival. Through PLCG1 controls NF-Kappa-B activation and the transcription of genes involved in cell survival. Through SHC1 and SH2B1 controls a Ras-PI3 kinase-AKT1 signaling cascade that is also regulating survival. In absence of ligand and activation, may promote cell death, making the survival of neurons dependent on trophic factors.

    Gene: NTRK1

    分子量
    87kDa
    基因ID
    4914
    UniProt
    P04629
    途径
    RTK signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process
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