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CAMK4 抗体 (pThr200)

CAMK4 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6256500
发货至: 中国
  • 抗原 See all CAMK4 抗体
    CAMK4 (Calcium/calmodulin-Dependent Protein Kinase IV (CAMK4))
    抗原表位
    • 19
    • 17
    • 11
    • 7
    • 6
    • 6
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    pThr200
    适用
    • 64
    • 53
    • 37
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 67
    • 12
    克隆类型
    • 60
    • 19
    多克隆
    标记
    • 48
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This CAMK4 antibody is un-conjugated
    应用范围
    • 70
    • 33
    • 19
    • 19
    • 14
    • 14
    • 11
    • 6
    • 5
    • 3
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    特异性
    Phospho-CaMK4 (Thr200) Antibody detects endogenous levels of CaMK4 only when phosphorylated at Threonine 200.
    预测反应
    Pig,Zebrafish,Horse,Sheep,Dog,Chicken,Xenopus
    纯化方法
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    免疫原
    A synthesized peptide derived from human CaMK4 around the phosphorylation site of Thr200.
    亚型
    IgG
    Top Product
    Discover our top product CAMK4 Primary Antibody
  • 应用备注
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • 抗原
    CAMK4 (Calcium/calmodulin-Dependent Protein Kinase IV (CAMK4))
    别名
    CAMK4 (CAMK4 产品)
    别名
    CaMK IV antibody, CaMK-GR antibody, IV antibody, caMK antibody, CAMK4 antibody, A430110E23Rik antibody, AI666733 antibody, CaMKIV antibody, CaMKIV/Gr antibody, D18Bwg0362e antibody, Ccdpk antibody, RATCCDPK antibody, camk4-A antibody, wu:fj42a03 antibody, zgc:110275 antibody, calcium/calmodulin dependent protein kinase IV antibody, calcium/calmodulin-dependent protein kinase IV antibody, calcium/calmodulin-dependent protein kinase IV L homeolog antibody, CAMK4 antibody, Camk4 antibody, camk4.L antibody, camk4 antibody
    背景

    Description: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4+/CD8+ double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18.

    Gene: CAMK4

    分子量
    60kDa
    基因ID
    814
    UniProt
    Q16566
    途径
    EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Production of Molecular Mediator of Immune Response, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma
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