(1 reference)-
- 抗原 See all SUFUH 抗体
- SUFUH (Suppressor of Fused Homolog (SUFUH))
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抗原表位
- AA 308-341, C-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SUFUH antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This SUFU antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 308-341 amino acids from the C-terminal region of human SUFU.
- 克隆位点
- RB53250
- 亚型
- Ig Fraction
- Top Product
- Discover our top product SUFUH Primary Antibody
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anti-Suppressor of Fused Homolog (SUFUH) (AA 325-484) antibody
SUFUH 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Fused Homolog (SUFUH) (AA 433-484) antibodySUFUH 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Fused Homolog (SUFUH) (AA 325-484) antibodySUFUH 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Fused Homolog (SUFUH) antibodySUFUH 适用: 人, 小鼠, Green Monkey WB, IHC (p) 宿主: 小鼠 Monoclonal 1783CT536-263-29 unconjugated
anti-Suppressor of Fused Homolog (SUFUH) (AA 1-484) antibodySUFUH 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Fused Homolog (SUFUH) (AA 181-280) antibodySUFUH 适用: 人 ELISA, PLA 宿主: 小鼠 Monoclonal 1B2 unconjugated
anti-Suppressor of Fused Homolog (SUFUH) (C-Term) antibodySUFUH 适用: 人, 小鼠, 大鼠, 兔, 犬, 豚鼠, 马, Pig, 猴, Bat, 小鸡, 非洲爪蟾 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Fused Homolog (SUFUH) (Middle Region) antibodySUFUH 适用: 人, 小鼠, 大鼠, 兔, 犬, 豚鼠, 马, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Fused Homolog (SUFUH) antibodySUFUH 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Suppressor of Fused Homolog (SUFUH) (AA 35-84) antibodySUFUH 适用: 人, 小鼠, 大鼠, 兔, 犬, 豚鼠, 马, Pig, Cow, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB: 1:2000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 有效期
- 6 months
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: "Nek2A phosphorylates and stabilizes SuFu: A new strategy of Gli2/Hedgehog signaling regulatory mechanism." in: Cellular signalling, Vol. 28, Issue 9, pp. 1304-13, (2017) (PubMed).
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: "Nek2A phosphorylates and stabilizes SuFu: A new strategy of Gli2/Hedgehog signaling regulatory mechanism." in: Cellular signalling, Vol. 28, Issue 9, pp. 1304-13, (2017) (PubMed).
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- 抗原
- SUFUH (Suppressor of Fused Homolog (SUFUH))
- 别名
- SUFU (SUFUH 产品)
- 别名
- CG6054 antibody, Dmel\\CG6054 antibody, SU(FU) antibody, SUFU antibody, Su(Fu) antibody, SuFu antibody, Sufu antibody, su(fu) antibody, sufu antibody, Xsufu antibody, sufuh antibody, sufuxl antibody, PRO1280 antibody, SUFUH antibody, SUFUXL antibody, Su(fu) antibody, dre antibody, fi39e05 antibody, wu:fi39e05 antibody, 2810026F04Rik antibody, b2b273Clo antibody, Suppressor of fused antibody, SUFU negative regulator of hedgehog signaling L homeolog antibody, SUFU negative regulator of hedgehog signaling antibody, suppressor of fused homolog (Drosophila) antibody, Su(fu) antibody, sufu.L antibody, SUFU antibody, sufu antibody, Sufu antibody
- 背景
- Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU- GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A). Required for the proper formation of hair follicles and the control of epidermal differentiation (By similarity).
- 分子量
- 53947
- UniProt
- Q9UMX1
- 途径
- Hedgehog Signaling, Tube Formation, Maintenance of Protein Location
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