DOT1L 抗体 (C-Term)
(2 references)-
- 抗原 See all DOT1L 抗体
- DOT1L (DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L))
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抗原表位
- AA 1390-1420, C-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This DOT1L antibody is un-conjugated
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应用范围
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- 免疫原
- This KMT4 / Dot1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1390~1420 amino acids from the C-terminal region of human DOT1L.
- 克隆位点
- RB2773
- 亚型
- Ig Fraction
- Top Product
- Discover our top product DOT1L Primary Antibody
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anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) (AA 3-108) antibody
DOT1L 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 6A6 unconjugated
anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) (AA 331-484) antibodyDOT1L 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) antibodyDOT1L 适用: 人 WB, IP 宿主: 兔 Monoclonal unconjugated
anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) (AA 51-150) antibodyDOT1L 适用: 人, 小鼠, 大鼠, Green Monkey WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) antibodyDOT1L 适用: 人 WB, ELISA 宿主: 兔 Monoclonal 3B6 unconjugated Recombinant Antibody
anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) (AA 3-108) antibodyDOT1L 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) (C-Term) antibodyDOT1L 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) (C-Term) antibodyDOT1L 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) (AA 250-500) antibodyDOT1L 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) (AA 1-250) antibodyDOT1L 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- IHC-P: 1:50~100
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 有效期
- 6 months
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- 抗原
- DOT1L (DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L))
- 别名
- KMT4 / Dot1L (DOT1L 产品)
- 别名
- NV11307 antibody, DOT1L antibody, DOT1 antibody, KMT4 antibody, A630076O07 antibody, AW907654 antibody, Dot1 antibody, mDot1 antibody, histone-lysine N-methyltransferase, H3 lysine-79 specific antibody, DOT1 like histone lysine methyltransferase antibody, histone methyltransferase antibody, DOT1-like, histone H3 methyltransferase (S. cerevisiae) antibody, LOC100116648 antibody, DOT1L antibody, DOT1 antibody, Dot1l antibody
- 背景
- Similar to acetylation and phosphorylation, histone methylation at the N-terminal tail has emerged as an important role in regulating chromatin dynamics and gene activity. Histone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET-domain-containing methyltransferase family. Five members have been identified in the arginine methyltransferase family. About 27 are grouped into the SET-domain family, and another 17 make up the PR domain family that is related to the SET domain family. The retinoblastoma protein-interacting zinc finger geneRIZ1 is a tumor suppressor gene and a FOUNDING member of the PR domain family. RIZ1 inactivation is commonly found in many types of human cancers and occurs through loss of mRNA expression, frame shift mutation, chromosomal deletion, and missense mutation. RIZ1 is also a tumor susceptibility gene in mice. The loss of RIZ1 mRNA in human cancers was shown to associate with DNA methylation of its promoter CpG island. Methylation of the RIZ1 promoter strongly correlated with lost or decreased RIZ1 mRNA expression in breast, liver, colon, and lung cancer cell lines as well as in liver cancer tissues.
- 分子量
- 164856
- NCBI登录号
- NP_115871
- UniProt
- Q8TEK3
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