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MAML3 抗体 (CF®594)

MAML3 适用: 人 FACS, IF, ISt 宿主: 小鼠 Monoclonal MAML3-1303 CF®594
产品编号 ABIN6188154
发货至: 中国
  • 抗原 See all MAML3 抗体
    MAML3 (Mastermind-Like 3 (MAML3))
    适用
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    宿主
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    小鼠
    克隆类型
    • 30
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    单克隆
    标记
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    This MAML3 antibody is conjugated to CF®594
    应用范围
    • 15
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    Flow Cytometry (FACS), Immunofluorescence (IF), Immunostaining (ISt)
    原理
    Mouse Monoclonal anti-MAML3 (MAML3/1303), CF594 Conjugate
    产品特性
    MAML3 (mastermind-like protein 3) is a nuclear speckle protein that acts as a transcriptional coactivator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML3 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML3 interacts with the ankyrin repeats of the Notch proteins Notch 1, Notch 2, Notch 3 and Notch 4.This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-J?, a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML3 is essential for proper Notch binding, the C-terminal domain of MAML3 is essential for transcriptional activation. Due to its involvement in cell signaling and transcriptional activation, upregulation of MAML3 is thought to be involved in oncogenesis. Primary antibodies are available purified, or with a selection of fluorescent CF® dyes and other labels. CF® dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
    免疫原
    Recombinant human full-length MAML3 protein
    克隆位点
    MAML3-1303
    亚型
    IgG1
    Top Product
    Discover our top product MAML3 Primary Antibody
  • 应用备注
    Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM Tris, 1 mM EDTA  pH 9.0 for 10-20 min followed by cooling at RT for 20 min
    • Immunofluorescence 0.5-1 μg/mL
    • Flow Cytometry 0.5-1 μg/million cells/0.1 mL
    • Optimal dilution for a specific application should be determined by user
    说明

    MCF-7 cells. Pancreas or Placenta. Cervix or Colon Carcinoma.

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    100 μg/mL
    缓冲液
    PBS/0.1 % BSA/0.05 % azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Protect from light
  • 抗原
    MAML3 (Mastermind-Like 3 (MAML3))
    别名
    MAML3 (MAML3 产品)
    别名
    AV234550 antibody, BC049812 antibody, Mam-2 antibody, mKIAA1816 antibody, Glrp1 antibody, CAGH3 antibody, ERDA3 antibody, GDN antibody, MAM-2 antibody, MAM2 antibody, TNRC3 antibody, mastermind like 3 (Drosophila) antibody, mastermind-like transcriptional coactivator 3 antibody, mastermind like transcriptional coactivator 3 antibody, Maml3 antibody, MAML3 antibody
    背景
    CAGH3, ERDA3, GDN, MAML3, Mastermind-like protein 3, TNRC3
    分子量
    150-170 kDa
    基因ID
    55534
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