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IL23A 抗体

IL23A 适用: 人 WB, IHC (p), IP, IHC (fro) 宿主: 小鼠 Monoclonal HLT2736 unconjugated
产品编号 ABIN614363
发货至: 中国
  • 抗原 See all IL23A 抗体
    IL23A (Interleukin 23, alpha subunit p19 (IL23A))
    适用
    • 44
    • 19
    • 8
    • 1
    宿主
    • 36
    • 8
    • 2
    • 1
    小鼠
    克隆类型
    • 39
    • 8
    单克隆
    标记
    • 33
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This IL23A antibody is un-conjugated
    应用范围
    • 32
    • 20
    • 7
    • 7
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))
    特异性
    Human recombinant p40 and p19 with elastin linker. The HLT2736 clone recognizes Human IL-23, a heterodimeric cytokine composed of the p40 subunit shared with IL-12 and a specific p19 subunit. This antibody recognizes heterodimeric IL-23, but does not react with the p40 subunit alone or recombinant IL-12(p70) when used as a Capture antibody in ELISA.
    交叉反应 (详细)
    Species reactivity (tested):Human.
    纯化方法
    Affinity Chromatography
    免疫原
    Recombinant protein
    克隆位点
    HLT2736
    亚型
    IgG1
    Top Product
    Discover our top product IL23A Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    PBS, pH 7.2 containing 0.09 % Sodium Azide as preservative
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store the antibody undiluted at 2-8 °C.
  • Botbol, Patel, Macian: "Common γ-chain cytokine signaling is required for macroautophagy induction during CD4+ T-cell activation." in: Autophagy, Vol. 11, Issue 10, pp. 1864-77, (2015) (PubMed).

    Muehlbauer, Lima, Goldman, Jacobson, Rivera, Goldberg, Palladino, Casadevall, Brojatsch: "Proteasome inhibitors prevent caspase-1-mediated disease in rodents challenged with anthrax lethal toxin." in: The American journal of pathology, Vol. 177, Issue 2, pp. 735-43, (2010) (PubMed).

    Katsifis, Rekka, Moutsopoulos, Pillemer, Wahl: "Systemic and local interleukin-17 and linked cytokines associated with Sjögren's syndrome immunopathogenesis." in: The American journal of pathology, Vol. 175, Issue 3, pp. 1167-77, (2009) (PubMed).

    Gueirard, Ave, Balazuc, Thiberge, Huerre, Milon, Guiso: "Bordetella bronchiseptica persists in the nasal cavities of mice and triggers early delivery of dendritic cells in the lymph nodes draining the lower and upper respiratory tract." in: Infection and immunity, Vol. 71, Issue 7, pp. 4137-43, (2003) (PubMed).

  • 抗原
    IL23A (Interleukin 23, alpha subunit p19 (IL23A))
    别名
    Interleukin-23 alpha / IL23A (IL23A 产品)
    别名
    IL-23 antibody, IL-23A antibody, IL23P19 antibody, P19 antibody, SGRF antibody, FIL1 antibody, FIL1(ZETA) antibody, FIL1Z antibody, IL-1F7 antibody, IL-1H antibody, IL-1H4 antibody, IL-1RP1 antibody, IL-37 antibody, IL1F7 antibody, IL1H4 antibody, IL1RP1 antibody, p19 antibody, il23p19 antibody, IL23 antibody, interleukin 23 subunit alpha antibody, interleukin 37 antibody, interleukin 23, alpha subunit p19 antibody, IL23A antibody, IL37 antibody, Il23a antibody
    背景
    The p19 shares sequence similarity with IL-6 subfamily members and is distantly related to the p35 subunit of IL-12. It shows no biological activity by itself, instead, it combines with the p40 subunit of IL-12 to form a biologically active, composite cytokine, IL-23. IL-23 shares some in vivo functions with IL-12, including the activation of the transcription factor Stat4. Similar to IL-12, human IL-23 stimulates IFN-g production and proliferation in PHA blast T cells, as well as in CD45RO (memory) T cells. Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death.Synonyms: IL-23 subunit alpha, IL-23p19, Interleukin-23 subunit p19, SGRF
    基因ID
    51561
    NCBI登录号
    NP_057668
    UniProt
    Q9NPF7
    途径
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
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