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HIF1AN 抗体 (AA 1-349)

HIF1AN 适用: 人 WB, IP, IF 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6141762
发货至: 中国
  • 抗原 See all HIF1AN 抗体
    HIF1AN (Hypoxia Inducible Factor 1, alpha Subunit Inhibitor (HIF1AN))
    抗原表位
    • 15
    • 10
    • 6
    • 6
    • 6
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-349
    适用
    • 84
    • 32
    • 22
    • 7
    • 7
    • 6
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    宿主
    • 76
    • 7
    克隆类型
    • 68
    • 17
    多克隆
    标记
    • 47
    • 5
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This HIF1AN antibody is un-conjugated
    应用范围
    • 48
    • 26
    • 15
    • 14
    • 14
    • 12
    • 11
    • 8
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF)
    序列
    MAATAAEAVA SGSGEPREEA GALGPAWDES QLRSYSFPTR PIPRLSQSDP RAEELIENEE PVVLTDTNLV YPALKWDLEY LQENIGNGDF SVYSASTHKF LYYDEKKMAN FQNFKPRSNR EEMKFHEFVE KLQDIQQRGG EERLYLQQTL NDTVGRKIVM DFLGFNWNWI NKQQGKRGWG QLTSNLLLIG MEGNVTPAHY DEQQNFFAQI KGYKRCILFP PDQFECLYPY PVHHPCDRQS QVDFDNPDYE RFPNFQNVVG YETVVGPGDV LYIPMYWWHH IESLLNGGIT ITVNFWYKGA PTPKRIEYPL KAHQKVAIMR NIEKMLGEAL GNPQEVGPLL NTMIKGRYN
    交叉反应
    人, 小鼠, 大鼠
    产品特性
    Polyclonal Antibodies
    纯化方法
    Affinity purification
    免疫原
    Recombinant fusion protein containing a sequence corresponding to amino acids 1-349 of human HIF1AN/FIH1 (NP_060372.2).
    亚型
    IgG
    Top Product
    Discover our top product HIF1AN Primary Antibody
  • 应用备注
    WB,1:500 - 1:2000,IF,1:50 - 1:200,IP,1:50 - 1:200
    说明

    HIGH QUALITY

    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Avoid freeze / thaw cycles.
  • 抗原
    HIF1AN (Hypoxia Inducible Factor 1, alpha Subunit Inhibitor (HIF1AN))
    别名
    HIF1AN (HIF1AN 产品)
    别名
    FIH1 antibody, 2310046M24Rik antibody, A830014H24Rik antibody, cb728 antibody, id:ibd5139 antibody, hypoxia inducible factor 1 alpha subunit inhibitor antibody, hypoxia-inducible factor 1, alpha subunit inhibitor antibody, hypoxia inducible factor 1, alpha subunit inhibitor antibody, hypoxia-inducible factor 1, alpha subunit inhibitor S homeolog antibody, HIF1AN antibody, Hif1an antibody, hif1an antibody, hif1an.S antibody
    背景
    Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD. Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.,HIF1AN,FIH1,Epigenetics & Nuclear Signaling,Cancer,Invasion and Metastasis,Cardiovascular,Hypoxia,HIF,HIF1AN
    分子量
    40 kDa
    基因ID
    55662
    UniProt
    Q9NWT6
    途径
    Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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