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INPP5D 抗体

INPP5D 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN5708392
发货至: 中国
  • 抗原 See all INPP5D 抗体
    INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))
    适用
    • 84
    • 58
    • 37
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    • 1
    人, 小鼠, 大鼠
    宿主
    • 83
    • 2
    克隆类型
    • 71
    • 14
    多克隆
    标记
    • 34
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    • 5
    • 5
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    This INPP5D antibody is un-conjugated
    应用范围
    • 61
    • 20
    • 16
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    纯化方法
    Antigen affinity purified
    免疫原
    Amino acids NEDDKFTVQASEGVSMRFFTKLDQLIEFYKKENMGLVTHLQ from the human protein were used as the immunogen for the SHIP1 antibody.
    亚型
    IgG
    Top Product
    Discover our top product INPP5D Primary Antibody
  • 应用备注
    Optimal dilution of the SHIP1 antibody should be determined by the researcher.\. Western blot: 0.5-1 μg/mL,IHC (FFPE): 1-2 μg/mL
    限制
    仅限研究用
  • 缓冲液
    0.5 mg/mL if reconstituted with 0.2 mL sterile DI water
    储存条件
    -20 °C
    储存方法
    After reconstitution, the SHIP1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
  • 抗原
    INPP5D (Inositol Polyphosphate-5-Phosphatase, 145kDa (INPP5D))
    别名
    SHIP1 (INPP5D 产品)
    别名
    INPP5D antibody, 256.t00004 antibody, 13.t00027 antibody, ship antibody, ship1 antibody, AI323613 antibody, SHIP antibody, SHIP-1 antibody, SHIP1 antibody, s-SHIP antibody, SIP-145 antibody, hp51CN antibody, inositol polyphosphate-5-phosphatase D antibody, phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 antibody, inositol polyphosphate 5-phosphatase antibody, inositol polyphosphate-5-phosphatase D L homeolog antibody, INPP5D antibody, LOC100446045 antibody, inpp5d antibody, EHI_159880 antibody, EHI_153490 antibody, inpp5d.L antibody, LOC100380693 antibody, Inpp5d antibody
    背景
    Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 1, also called Inositol polyphosphate-5-phosphatase of 145 kDa, SIP-145 and SH2 domain-containing inositol phosphatase 1 (SHIP1), is an enzyme that in humans is encoded by the INPP5D gene. This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system.
    UniProt
    Q92835
    途径
    TCR Signaling, BCR Signaling, Warburg Effect
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